| Cutting edge: abortive proliferation of CD46-induced Tr1-like cells due to a defective Akt/Survivin signaling pathway. | |
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MedLine Citation:
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PMID: 17015676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T regulatory cell 1 (Tr1) are low proliferating peripherally induced suppressive T cells. Engaging CD3 and CD46 on human CD4+ T cells induces a Tr1-like phenotype. In this study, we report that human Tr1-like cells do not sustain proliferation over time. The weak proliferation of these cells results first from their inability to sustain expression of various cell cycle-associated proteins, to efficiently degrade the inhibitor of cell cycle progression p27/Kip1 and, as a consequence, in their accumulation in the G0-G1 phase. Also, the reduced proliferation of Tr1-like cells results from their increased sensitivity to death as they divide, through a mechanism that is neither Fas-mediated nor Bcl2/Bcl-xL related. Both properties, impaired cell cycle and death sensitivity, are explained by a specific defective activation of Akt that impairs the expression of Survivin. Thus, our results show that CD3/CD46-induced Tr1-like cells die through a process of abortive proliferation. |
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Authors:
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Grégory Meiffren; Monique Flacher; Olga Azocar; Chantal Rabourdin-Combe; Mathias Faure |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 177 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-03 Completed Date: 2007-02-06 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 4957-61 Citation Subset: AIM; IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale Unité 503-IFR 128-BioSciences Lyon-Gerland-Université Claude-Bernard-Lyon 1, Lyon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD3
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physiology Antigens, CD46 / physiology* Cell Cycle Cell Death Cell Proliferation* Humans Intracellular Signaling Peptides and Proteins / metabolism Microtubule-Associated Proteins / physiology* Neoplasm Proteins / physiology* Proto-Oncogene Proteins c-akt / physiology* Signal Transduction* T-Lymphocytes, Regulatory / cytology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Antigens, CD46; 0/BIRC5 protein, human; 0/CDKN1B protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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