| Cutting edge: Lack of evidence for connexin-43 expression in human epidermal Langerhans cells. | |
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MedLine Citation:
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PMID: 17878326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A provocative study has shown that viral peptides may be transferred in vitro from epithelial cells to APC through connexin-43 gap junction channels. In support of this cross-presentation pathway, the study also reported that human dendritic cells, including Langerhans cells of skin, express connexin-43. In this report we show that if this was the case, the levels of connexin-43 are below those detectable by immunofluorescence, flow cytometry, quantitative PCR of purified CD1a+ cells, and electron microscopy, raising questions about the relevance of the connexin-43-dependent mechanism for Langerhans cells of noninflamed human skin. |
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Authors:
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Simone C Zimmerli; Florence Masson; José Cancela; Paolo Meda; Conrad Hauser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 179 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-19 Completed Date: 2007-11-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 4318-21 Citation Subset: AIM; IM |
Affiliation:
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Division of Immunology and Allergy, Department of Internal Medicine, Geneva University Hospitals and Medical School, Switzerland. Simone.Zimmerli@hcuge.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Separation Connexin 43 / genetics, immunology, metabolism* Epidermis / cytology* Gap Junctions / metabolism Gene Expression Humans Keratinocytes / metabolism, ultrastructure Langerhans Cells / metabolism* Microscopy, Immunoelectron |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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