Document Detail

Cutting edge: Lack of evidence for connexin-43 expression in human epidermal Langerhans cells.
MedLine Citation:
PMID:  17878326     Owner:  NLM     Status:  MEDLINE    
A provocative study has shown that viral peptides may be transferred in vitro from epithelial cells to APC through connexin-43 gap junction channels. In support of this cross-presentation pathway, the study also reported that human dendritic cells, including Langerhans cells of skin, express connexin-43. In this report we show that if this was the case, the levels of connexin-43 are below those detectable by immunofluorescence, flow cytometry, quantitative PCR of purified CD1a+ cells, and electron microscopy, raising questions about the relevance of the connexin-43-dependent mechanism for Langerhans cells of noninflamed human skin.
Simone C Zimmerli; Florence Masson; José Cancela; Paolo Meda; Conrad Hauser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  179     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2007-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4318-21     Citation Subset:  AIM; IM    
Division of Immunology and Allergy, Department of Internal Medicine, Geneva University Hospitals and Medical School, Switzerland.
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MeSH Terms
Cell Separation
Connexin 43 / genetics,  immunology,  metabolism*
Epidermis / cytology*
Gap Junctions / metabolism
Gene Expression
Keratinocytes / metabolism,  ultrastructure
Langerhans Cells / metabolism*
Microscopy, Immunoelectron
Reg. No./Substance:
0/Connexin 43

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