| Cutting edge: CD47 controls the in vivo proliferation and homeostasis of peripheral CD4+ CD25+ Foxp3+ regulatory T cells that express CD103. | |
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MedLine Citation:
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PMID: 18832672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral CD103(+)Foxp3(+) regulatory T cells (Tregs) can develop both from conventional naive T cells upon cognate Ag delivery under tolerogenic conditions and from thymic-derived, expanded/differentiated natural Tregs. We here show that CD47 expression, a marker of self on hematopoietic cells, selectively regulated CD103(+)Foxp3(+) Treg homeostasis at the steady state. First, the proportion of effector/memory-like (CD44(high)CD62L(low)) CD103(+)Foxp3(+) Tregs rapidly augmented with age in CD47-deficient mice (CD47(-/-)) as compared with age-matched control littermates. Yet, the percentage of quiescent (CD44(low)CD62L(high)) CD103(-)Foxp3(+) Tregs remained stable. Second, the increased proliferation rate (BrdU incorporation) observed within the CD47(-/-)Foxp3(+) Treg subpopulation was restricted to those Tregs expressing CD103. Third, CD47(-/-) Tregs maintained a normal suppressive function in vitro and in vivo and their increased proportion in old mice led to a decline of Ag-specific T cell responses. Thus, sustained CD47 expression throughout life is critical to avoid an excessive expansion of CD103(+) Tregs that may overwhelmingly inhibit Ag-specific T cell responses. |
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Authors:
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Vu Quang Van; Jinane Darwiche; Marianne Raymond; Sylvie Lesage; Salim Bouguermouh; Manuel Rubio; Marika Sarfati |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 181 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-03 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 5204-8 Citation Subset: AIM; IM |
Affiliation:
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Immunoregulation, Centre Hospitalier de l'Université de Montréal, Research Center, l'Hôpital Notre-Dame, Montréal, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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genetics,
immunology Animals Antigens / genetics, immunology Antigens, CD / genetics, immunology* Antigens, CD47 / genetics, immunology* Cell Proliferation Forkhead Transcription Factors / genetics, immunology* Gene Expression Regulation / genetics, immunology* Immunologic Memory* / genetics Integrin alpha Chains / genetics, immunology* Mice Mice, Inbred BALB C Mice, Knockout T-Lymphocytes, Regulatory / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, CD; 0/Antigens, CD47; 0/Cd47 protein, mouse; 0/Forkhead Transcription Factors; 0/Foxp3 protein, mouse; 0/Integrin alpha Chains; 0/alpha E integrins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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