Document Detail

Cutting balloon angioplasty in percutaneous carotid interventions.
MedLine Citation:
PMID:  19090627     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report a prospective feasibility study of cutting balloon angioplasty (CBA) applied in the predilation phase of carotid artery stenting (CAS) in highly calcified lesions. METHODS: From January 2003 to February 2007, 178 consecutive patients (109 men; mean age 73.1+/-7.3 years) with highly calcified carotid lesions underwent CAS with CBA applied as a pre-specified strategy in the predilation phase of the procedure. All steps in the procedure were performed under cerebral filter protection. The cutting balloon ranged in diameter from 3 to 4 mm and was inflated at nominal pressures in the target lesion. Pre-CBA dilation with a low-profile coronary balloon was performed only when the cutting balloon was not able to cross the lesion. Selection of the filters and stents was at the operator's discretion. Primary endpoints were the all stroke and death rates at 30 days and 6 months. Secondary endpoints included cutting balloon success (positioning and full balloon inflation), CAS technical success (residual angiographic stenosis <30%), CAS procedural success (technical success and no complications), and in-hospital major complications. RESULTS: Cutting balloon success was achieved in all 178 patients. In 32 (18.0%), pre-CBA dilation was necessary due to inability to cross the lesion with the cutting balloon initially. CAS technical success was achieved in all patients. One (0.6%) patient suffered transient neurological intolerance due to flow cessation from massive debris in the distal filter; this event was completely resolved after the filter was removed (CAS procedural success 99.4%). One patient suffered a major stroke at day 15 (0.6% 30-day all stroke and death rate). At the 6-month follow-up, 174 (97.7%) patients were evaluated; 1 patient died from myocardial infarction at day 35, and 2 patients died from non-neurological or cardiac causes at days 103 and 158. The cumulative all stroke and death rate was 2.2%. CONCLUSION: These data suggest that CBA performed during the predilation phase of CAS in highly calcified lesion is a safe and useful method to prepare this lesion subset for stenting.
Fausto Castriota; Estêvão Carvalho de Campos Martins; Carlo Setacci; Raffaella Manetti; Hazem Khamis; Barbara Spagnolo; Alessandro Furgieri; Shane Gieowarsingh; Sepideh Torabi Parizi; Paolo Bianchi; Francesco Setacci; Gianmarco de Donato; Alberto Cremonesi
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists     Volume:  15     ISSN:  1526-6028     ISO Abbreviation:  J. Endovasc. Ther.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896915     Medline TA:  J Endovasc Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-62     Citation Subset:  IM    
Interventional Cardio-Angiology Unit, Villa Maria Cecilia Hospital, Cotignola, Italy.
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MeSH Terms
Aged, 80 and over
Angioplasty, Balloon / adverse effects,  instrumentation,  methods*,  mortality
Calcinosis / mortality,  radiography,  therapy*
Carotid Artery Diseases / mortality,  radiography,  therapy*
Feasibility Studies
Middle Aged
Myocardial Infarction / etiology,  mortality
Pilot Projects
Prospective Studies
Prosthesis Design
Risk Assessment
Stroke / etiology,  mortality
Time Factors
Treatment Outcome

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