| Cutting Edge: Unusual NK cell responses to HIV-1 peptides are associated with protection against maternal-infant transmission of HIV-1. | |
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MedLine Citation:
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PMID: 19414742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most infants exposed to HIV-1 in utero and at delivery do not acquire infection. We show that mothers and infants who have CD3-negative cells that respond to HIV-1 peptides are substantially less likely to transmit and acquire infection, respectively. The CD3-negative cells, shown to be NK cells, respond with remarkable specificity and high magnitude to HIV-1 peptides from Env (envelope) and Reg (regulatory) protein regions, as measured by a whole blood intracellular cytokine assay only in the context of HIV-1 infection or exposure. These findings identify an important new measure of protective immunity to HIV-1 that highlights the importance of innate immunity in preventing the establishment of HIV-1 infection. |
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Authors:
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Caroline T Tiemessen; Sharon Shalekoff; Stephen Meddows-Taylor; Diana B Schramm; Maria A Papathanasopoulos; Glenda E Gray; Gayle G Sherman; Ashraf H Coovadia; Louise Kuhn |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 182 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-05-26 Revised Date: 2011-05-04 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 5914-8 Citation Subset: AIM; IM |
Affiliation:
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AIDS Virus Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD3
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immunology Cytokines / metabolism Female Flow Cytometry HIV Infections / transmission* HIV-1 / immunology* Humans Infant, Newborn Infectious Disease Transmission, Vertical* Killer Cells, Natural / immunology* Polymerase Chain Reaction Pregnancy Pregnancy Complications, Infectious / immunology Viral Proteins / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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076352//Wellcome Trust; 076352/Z/05/Z//Wellcome Trust; R01 HD042402-01A1/HD/NICHD NIH HHS; R01 HD042402-02/HD/NICHD NIH HHS; R01 HD042402-03/HD/NICHD NIH HHS; R01 HD042402-04/HD/NICHD NIH HHS; R01 HD042402-05/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Cytokines; 0/Viral Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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