| Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential. | |
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MedLine Citation:
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PMID: 21795595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The RGS1 gene is associated with celiac disease, multiple sclerosis, and type I diabetes, which are all T cell-mediated pathologies, yet there is no reported analysis of regulator of G protein signaling (RGS)1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, whereas RGS1 depletion selectively enhances such chemotaxis in gut T cells and impairs their colitogenic potential. These findings provide a revised framework in which to view the linkage of RGS1 to inflammatory disease. |
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Authors:
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Deena L Gibbons; Lucie Abeler-Dörner; Tim Raine; Il-Young Hwang; Anett Jandke; Melanie Wencker; Livija Deban; Christopher E Rudd; Peter M Irving; John H Kehrl; Adrian C Hayday |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-07-27 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 187 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-22 Completed Date: 2011-10-19 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 2067-71 Citation Subset: AIM; IM |
Affiliation:
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Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement* Cell Separation Chemotaxis, Leukocyte / immunology* Colitis / immunology*, metabolism Flow Cytometry Humans Immunity, Mucosal / immunology* Intestinal Mucosa / immunology*, metabolism Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal RGS Proteins / immunology*, metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction / immunology T-Lymphocytes / cytology, immunology*, metabolism Transfection |
| Grant Support | |
ID/Acronym/Agency:
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Z01 AI000738-12/AI/NIAID NIH HHS; Z01 AI000739-12/AI/NIAID NIH HHS; //Cancer Research UK; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/RGS Proteins; 0/RGS1 protein, human |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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