| Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. | |
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MedLine Citation:
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PMID: 20208006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although B cells have been shown to possess a regulatory function, microenvironmental factors or cytokines involved in the induction of regulatory B cells remain largely uncharacterized. B cell-activating factor (BAFF), a member of TNF family cytokines, is a key regulator for B cell maturation and function. In this study, we detected significantly increased numbers of IL-10-producing B cells in BAFF-treated B cell cultures, an effect specifically abrogated by neutralization of BAFF with TACI-Fc. BAFF-induced IL-10-producing B cells showed a distinct CD1d(hi)CD5(+) phenotype, which were mainly derived from marginal zone B cells. Moreover, BAFF activated transcription factor AP-1 for binding to IL-10 promoter. Notably, BAFF treatment in vivo increased the number of IL-10-producing B cells in marginal zone regions. Furthermore, BAFF-induced IL-10-producing B cells possess a regulatory function both in vitro and in vivo. Taken together, our findings identify a novel function of BAFF in the induction of IL-10-producing regulatory B cells. |
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Authors:
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Min Yang; Lingyun Sun; Shengjun Wang; King-Hung Ko; Huaxi Xu; Bo-Jian Zheng; Xuetao Cao; Liwei Lu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-05 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 184 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 3321-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Cell Activating Factor / immunology*, metabolism B-Lymphocyte Subsets / immunology*, metabolism B-Lymphocytes / immunology*, metabolism Cell Differentiation / immunology* Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Gene Expression Gene Expression Regulation / immunology Interleukin-10 / biosynthesis*, immunology Mice Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction Transcription Factor AP-1 / biosynthesis, immunology |
| Chemical | |
Reg. No./Substance:
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0/B-Cell Activating Factor; 0/Tnfsf13b protein, mouse; 0/Transcription Factor AP-1; 130068-27-8/Interleukin-10 |
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