Document Detail


Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner.
MedLine Citation:
PMID:  20368279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IL-21 produced by follicular Th (Tfh) cells is an important regulator of Tfh cell development and B cell responses, including germinal center (GC) formation. However, whether defective GC formation and Ab responses are a consequence of impaired Tfh cells development or a B cell-intrinsic defect in IL-21-deficient mice requires clarification. To address this question, we generated chimeric mice lacking IL-21R exclusively on B cells. In this study, we demonstrate that GC reaction and B cell responses induced by immunization with virus-like particles were strongly reduced in both global and B cell-specific IL-21R-deficient mice. Interestingly, the presence of TLR7 ligand within virus-like particles largely restored defective GC reaction and Ab responses in global as well as in B cell-specific IL-21R-deficient mice. Hence, IL-21 acts directly on B cells and cooperates with TLR signaling for optimal B cell responses.
Authors:
Juliana Bessa; Manfred Kopf; Martin F Bachmann
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Publication Detail:
Type:  Journal Article     Date:  2010-04-05
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  184     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4615-9     Citation Subset:  AIM; IM    
Affiliation:
Cytos Biotechnology, Wagistrasse 25, Schlieren 8952, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Allolevivirus / genetics,  immunology
Animals
Antibodies, Viral / biosynthesis
B-Lymphocyte Subsets / immunology*,  metabolism*,  virology
Epitopes, T-Lymphocyte / genetics,  immunology
Gene Expression Regulation, Viral / immunology
Gene Products, env / biosynthesis,  genetics,  physiology
Germinal Center / cytology,  immunology*,  metabolism*,  virology
Immunity, Innate / genetics
Immunoglobulin G / biosynthesis
Interleukins / metabolism,  physiology*
Ligands
Membrane Glycoproteins / metabolism,  physiology*
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Interleukin-21 / deficiency,  genetics
Recombinant Proteins / biosynthesis,  genetics
Signal Transduction / immunology*
T-Lymphocytes, Helper-Inducer / immunology,  metabolism,  virology
Toll-Like Receptor 7 / metabolism,  physiology*
Toll-Like Receptor 8 / metabolism,  physiology*
Virion / genetics,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Epitopes, T-Lymphocyte; 0/Gene Products, env; 0/Immunoglobulin G; 0/Interleukins; 0/Ligands; 0/Membrane Glycoproteins; 0/Receptors, Interleukin-21; 0/Recombinant Proteins; 0/Tlr7 protein, mouse; 0/Toll-Like Receptor 7; 0/Toll-Like Receptor 8; 0/interleukin-21

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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