| Cutting edge: A critical functional role for IL-23 in psoriasis. | |
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MedLine Citation:
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PMID: 20956338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23-dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders. |
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Authors:
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Giulia Tonel; Curdin Conrad; Ute Laggner; Paola Di Meglio; Katarzyna Grys; Terrill K McClanahan; Wendy M Blumenschein; Jian-Zhong Qin; Hong Xin; Elizabeth Oldham; Robert Kastelein; Brian J Nickoloff; Frank O Nestle |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-18 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2010-12-02 Revised Date: 2011-01-21 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 5688-91 Citation Subset: AIM; IM |
Affiliation:
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St. John's Institute of Dermatology, National Institute for Health Research Biomedical Research Centre, King's College London, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / therapeutic use Cell Separation Disease Models, Animal Flow Cytometry Humans Immunohistochemistry Interleukin-23 / antagonists & inhibitors*, immunology* Mice Psoriasis / drug therapy, immunology*, metabolism Receptors, Interleukin / immunology, metabolism Reverse Transcriptase Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
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G0601387//Medical Research Council; GR078173MA//Wellcome Trust; R01AR040065/AR/NIAMS NIH HHS; //Department of Health |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/IL23R protein, human; 0/Interleukin-23; 0/Receptors, Interleukin |
| Comments/Corrections | |
Comment In:
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Nat Rev Rheumatol. 2011 Jan;7(1):4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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