Document Detail

Cutaneous and systemic plasmacytosis: a Chinese case.
MedLine Citation:
PMID:  18789075     Owner:  NLM     Status:  MEDLINE    
Cutaneous and systemic plasmacytosis (CSP) is an exceedingly rare condition arising primarily in patients of Japanese descent. Herein, we describe a patient of mainland Chinese origin suffering CSP. A 49-year-old Chinese male had asymptomatic brownish-red plaques and papules of the face and trunk for 6 years. Physical examination revealed innumerable symmetric red-brownish macules on face and trunk with fewer red-brownish papules scattered among the macules. Chemical analysis revealed hypergammaglobulinemia. Computerized tomography scan discovered some lymphadenopathy in the axillary, paratracheal and pulmonary regions. Histological examination showed focal perivascular and periadnexal infiltrate of mainly plasma cells in the superficial and deep dermis. Immunohistochemical study showed that a great number of the infiltrating cells were CD20-positive. The infiltrated polyclonal plasma cells expressed both kappa and lambda light chains. Topical therapy with tacrolimus 0.1% ointment for 2 months reduced the thickness and pigmentation of the facial skin lesions. The lesions resumed the original appearance 3 weeks after discontinuing the therapy. To the best of our knowledge, this is the first case of CSP from mainland China.
Hui-Jun Ma; Wen Liu; You Li; Guang Zhao; Ru-Song Meng; Dong-Guang Li
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  35     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  536-40     Citation Subset:  IM    
Department of Dermatology, The Airforce General Hospital of Chinese People's Liberation Army, Beijing, China.
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MeSH Terms
Administration, Topical
Antigens, CD20 / analysis
Asian Continental Ancestry Group
Immunoglobulin Light Chains
Lymphatic Diseases
Middle Aged
Ointment Bases
Plasma Cells / pathology*
Skin / pathology*
Skin Diseases / diagnosis*,  drug therapy,  pathology*
Tacrolimus / administration & dosage
Reg. No./Substance:
0/Antigens, CD20; 0/Immunoglobulin Light Chains; 0/Ointment Bases; 109581-93-3/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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