Document Detail


Cutaneous squamous cell carcinoma in organ transplant recipients: a study of the Swedish cohort with regard to tumor site.
MedLine Citation:
PMID:  15837862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To establish the anatomical site distribution of cutaneous squamous cell carcinoma (SCC) in organ transplant recipients (OTRs) with regard to age and sex. DESIGN: Retrospective population-based cohort study of OTRs. SETTING: Patients who underwent organ transplantation in Sweden from January 1, 1970, to December 31, 1997, registered in the Swedish In-patient Registry and national Swedish Cancer Registry. PATIENTS: From the cohort of 5931 OTRs, we could include 179 patients with 475 cutaneous SCCs. Information on the sites was received from the cancer registry and from the histopathological reports. RESULTS: The site of each SCC was registered in a computer program displaying the results on a 3-dimensional human figure. The head and neck were the predominant sites in male patients, and the trunk was the predominant site in female patients. The most common site in younger patients (born in 1940 or after) was the chest; and in older patients, the face. The ear was a common site in male patients, but, in contrast, no tumors were located there in female patients. Overall, the OTRs were younger compared with the overall Swedish population with cutaneous SCC. CONCLUSIONS: There are differences in the anatomical site distribution of cutaneous SCCs in OTRs with regard to sex and age, and with regard to the general distribution in Swedish patients. The level of sun exposure is considered the most important factor in explaining those differences, and highlights the importance of sun avoidance in this group of patients.
Authors:
Bernt Lindelöf; Henrik Dal; Katarina Wolk; Niklas Malmborg
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  141     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2005-05-10     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-51     Citation Subset:  AIM; IM    
Affiliation:
Unit of Dermatology and Venereology, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. bernt.lindelof@karolinska.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Aged
Carcinoma, Squamous Cell / diagnosis,  epidemiology*
Cohort Studies
Female
Graft Survival
Head and Neck Neoplasms / diagnosis,  epidemiology*
Humans
Immunocompromised Host*
Incidence
Male
Middle Aged
Organ Transplantation / adverse effects*,  methods
Registries
Retrospective Studies
Risk Assessment
Sex Distribution
Skin Neoplasms / diagnosis,  epidemiology*
Survival Rate
Sweden / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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