Document Detail


Cutaneous sporotrichosis. Intermittent treatment (pulses) with itraconazole.
MedLine Citation:
PMID:  18086591     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sporotrichosis is a subcutaneous and exceptionally deep mycosis caused by a dimorphic fungus, Sporothrix schenckii. Itraconazole is a triazole derivative leading to good results in the treatment of sporotrichosis. Patients with cutaneous sporotrichosis proven with mycological tests (direct examination and culture) were enrolled. All patients underwent laboratory tests (at baseline and on a monthly basis) and received oral itraconazole 400 mg/day for one week with a 3-week break (pulses); thereafter the drug was administered as pulses until clinical and mycological cure was achieved. Five patients with sporotrichosis were enrolled, 4 with cutaneous lymphangitic form and one with fixed cutaneous form. Clinical and mycological cure was achieved in 4/5 cases (80%), with a mean number of pulses of 3.5. No patient had side effects and no laboratory test abnormalities occurred. Intermittent or pulsed itraconazole was effective in treating cutaneous sporotrichosis. It may be considered as a new treatment choice that entails an important reduction in total medication use.
Authors:
Alexandro Bonifaz; Leonel Fierro; Amado Saúl; Rosa María Ponce
Publication Detail:
Type:  Journal Article     Date:  2007-12-18
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  18     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Affiliation:
Dermatology Service & Mycology Department, Hospital General de México OD, Sánchez Azcona 317 int 202, Col del Valle, 03020 Mexito City, Mexico. a_bonifaz@yahoo.com.mx
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antifungal Agents / administration & dosage*
Female
Humans
Itraconazole / administration & dosage*
Male
Middle Aged
Pulse Therapy, Drug
Sporotrichosis / drug therapy*,  pathology
Chemical
Reg. No./Substance:
0/Antifungal Agents; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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