Document Detail


Cutaneous sensitivity to atracurium and vecuronium in patients suffering anaphylactoid reactions to neuromuscular blockers.
MedLine Citation:
PMID:  2864882     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using an ordinal measure of cutaneous sensitivity to intradermal injections of atracurium and vecuronium, 40 nonreacting subjects were compared with a group of 24 patients previously suffering life-threatening anaphylactoid reactions to other muscle relaxants. Enhanced cutaneous sensitivity to vecuronium was found in three, and to atracurium in two of the previously reacting group. With the exception of those showing abnormal reactivity, no significant difference was found in the distribution of cutaneous sensitivity in the control and reacting group. A concentration of vecuronium 8.75 times that of atracurium was required to produce an equivalent intradermal wheal response.
Authors:
D C Galletly; B C Treuren
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  13     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-11-20     Completed Date:  1985-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / chemically induced,  prevention & control*
Atracurium
Drug Hypersensitivity / diagnosis*
Humans
Intradermal Tests*
Isoquinolines / adverse effects*
Neuromuscular Blocking Agents / adverse effects*
Pancuronium / adverse effects,  analogs & derivatives*
Skin Tests*
Vecuronium Bromide
Chemical
Reg. No./Substance:
0/Isoquinolines; 0/Neuromuscular Blocking Agents; 0/Pancuronium; 50700-72-6/Vecuronium Bromide; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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