Document Detail


Cutaneous sarcoidosis: clinical profile of 23 Indian patients.
MedLine Citation:
PMID:  17314441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sarcoidosis is a multisystem disease of undetermined etiology. Indian studies on cutaneous sarcoidosis are not many and mainly comprise case reports. AIMS: This retrospective study was carried out to assess the clinical profile of sarcoidosis patients presenting with cutaneous lesions. METHODS: All histopathologically proven cases of cutaneous sarcoidosis seen consecutively between 1999 and 2004 were studied. Their age, sex, presenting features, evolution of disease and laboratory parameters were analyzed. RESULTS: A total of 23 patients (F:M 15:8) between 31 to 78 years (mean 44.3 years) of age had the mean duration of skin lesions of 1.4 years. Six patients had one to four lesions; two patients each had scar sarcoidosis and angiolupoid and one patient each had recurrent erythema nodosum, leg lymphedema and subcutaneous sarcoidosis. Others showed combination of papules, nodules, plaques and psoriasiform lesions. Peripheral lymph nodes were involved in two patients. Among 10 patients of pulmonary involvement, three had become symptomatic four months to four years after the cutaneous lesions. Routine laboratory investigations including serum calcium estimation were normal in all cases. Serum angiotensin-converting enzyme levels were raised in 3 out of 6 patients. Asymptomatic lytic lesions of digital bones were detected in hand X-ray of one patient. CONCLUSION: Skin lesions of sarcoidosis are like the tip of an iceberg indicating more changes in other organs. The symptomatology and abnormal laboratory results do not necessarily correlate with the severity of cutaneous involvement in general.
Authors:
Vikram K Mahajan; Nand Lal Sharma; Ramesh Chander Sharma; Vikas C Sharma
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of dermatology, venereology and leprology     Volume:  73     ISSN:  0973-3922     ISO Abbreviation:  Indian J Dermatol Venereol Leprol     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701852     Medline TA:  Indian J Dermatol Venereol Leprol     Country:  India    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Asian Continental Ancestry Group*
Erythema Nodosum / complications
Female
Granuloma / etiology
Humans
India
Leg
Lung Diseases / etiology
Lymph Nodes / pathology
Lymphedema / complications
Male
Middle Aged
Peptidyl-Dipeptidase A / blood
Retrospective Studies
Sarcoidosis / complications,  ethnology,  pathology*,  physiopathology*
Skin Diseases / complications,  ethnology,  pathology*,  physiopathology*
Uveitis / etiology
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

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