Document Detail


Cutaneous penetration of bisphenol A in pig skin.
MedLine Citation:
PMID:  18338280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bisphenol A (BPA) is an endocrine disruptor with weak estrogenic activity, used in epoxy resin and polycarbonate plastic. Human exposure may occur by contamination from food or food-contact material and by occupational scenarios. Occupational health hazards may be associated with allergic contact dermatitis (ACD) secondary to BPA exposure. Most ACD occurs in workers handling BPA products, such as plastic-product workers, and those exposed to epoxy adhesive tapes, foams, and dental products. The present study examined in vitro cutaneous penetration of BPA through pig skin, using a Franz cell. After 2, 5, and 10 h of exposure, total BPA skin content was 3, 6.9, and 11.4% of the applied dose, respectively. BPA remained essentially on the skin surface and penetration mainly accumulated in the dermis. As the pig skin model is a reliable predictor of percutaneous penetration in humans, these findings may be reassuring for workers in contact with BPA-based products.
Authors:
Nisrin Kaddar; Catherine Harthé; Henri Déchaud; Elizabeth Mappus; Michel Pugeat
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health. Part A     Volume:  71     ISSN:  1528-7394     ISO Abbreviation:  J. Toxicol. Environ. Health Part A     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-13     Completed Date:  2008-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960995     Medline TA:  J Toxicol Environ Health A     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-3     Citation Subset:  IM    
Affiliation:
INSERM U863, Lyon, France. nkaddar@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Dermatitis, Occupational
Disease Models, Animal
Endocrine Disruptors / pharmacokinetics*
Female
Humans
Occupational Exposure
Phenols / pharmacokinetics*
Skin Absorption
Sus scrofa
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Phenols; 80-05-7/bisphenol A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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