Document Detail

Cutaneous papillomatous hyperplasia in cyclosporine-A treated beagles.
MedLine Citation:
PMID:  2754276     Owner:  NLM     Status:  MEDLINE    
All twelve Beagle dogs undergoing long-term therapy (26 weeks) with the immunosuppressive drug cyclosporine-A (30 mg/kg), developed cutaneous papillomatous hyperplasia. By week 7 all dogs developed generalized lesions distributed over the entire body. These occurred as irregular, oval, sessile, unpigmented, firm masses. The incidence and severity of the skin lesions varied among dogs and anatomic site, with no correlation to the blood level of cyclosporine. Microscopic analysis revealed that the epidermis formed short papillary folds on broad fibrovascular stalks and was hyperkeratotic and acanthotic. Mild hyperplasia of hair follicles and sebaceous glands was also evident. A mild diffuse infiltrate of lymphocytes and plasma cells was present in the papillary dermis. No histopathologic changes typical of papillomavirus infection were identified, nor were papillomavirus group-specific antigens or viral DNA detected. Other cutaneous side effects included hyperkeratosis of footpads, increased growth of hair and nails, and hyperkeratinization of the haired skin of the prepuce. All cutaneous lesions regressed spontaneously within 8 weeks following termination of cyclosporine administration. The hyperplastic lesions may have resulted from the action of cyclosporine via the T-lymphocyte system. Conversely a direct action of this drug on epithelial cells may have stimulated proliferation and keratinization.
W Seibel; J P Sundberg; L J Lesko; J J Sauk; L B McCleary; T M Hassell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  93     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-30     Citation Subset:  IM    
Dental School, University of Maryland, Baltimore 21201.
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MeSH Terms
Cyclosporins / adverse effects,  blood
Osmolar Concentration
Papilloma / chemically induced*,  metabolism,  pathology
Skin Neoplasms / chemically induced*,  metabolism,  pathology
Grant Support
Reg. No./Substance:

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