Document Detail

Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
MedLine Citation:
PMID:  19922484     Owner:  NLM     Status:  MEDLINE    
Cutaneous schwannomas in their classical form are readily identified histologically. A number of variants, including ancient, cellular, epithelioid, plexiform, microcystic and neuroblastoma-like, may cause diagnostic difficulty and rarely be confused with malignancy. Neuroblastoma-like schwannoma was first described by Goldblum et al. in 1994, and very few cases have since been reported. It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures. The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma. We describe two further cases of this rare entity and review the literature on the subject. Our first case additionally has a plexiform multinodular pattern, a feature described in only one previous report.
Ravi Suchak; Bostjan Luzar; Carlos E Bacchi; Brigid Maguire; Eduardo Calonje
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-11-17
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  997-1001     Citation Subset:  IM    
Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, Lambeth Palace Road, London, UK.
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MeSH Terms
Neurilemmoma / metabolism,  pathology*,  surgery
Neuroblastoma / metabolism,  pathology*
Skin Neoplasms / metabolism,  pathology*,  surgery
Treatment Outcome
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Tumor Markers, Biological

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