Document Detail


Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study.
MedLine Citation:
PMID:  9565347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although pruritus is the cardinal symptom of atopic dermatitis, its mechanism is not well understood. Free nerve endings in the skin are involved in pruritus as itching receptors. We studied the cutaneous nerve fibres in lichenified lesions of 16 patients with adult atopic dermatitis. On immunohistochemistry, fibres immunoreactive for neurofilament, neuron-specific enolase, and protein gene product 9.5 were observed in the papillary dermis and dermoepidermal junctions as well as in the epidermis. In these areas, no fibres stained positively for substance P, neuropeptide Y, vasoactive intestinal peptide, beta endorphin, somatostatin or serotonin. On electron microscopy, the ultrastructure of subepidermal and intraepidermal free nerve endings appeared to be essentially normal. However, the distribution density of the cutaneous nerve fibres was much higher than in normal controls, and the diameter of these fibres was much larger, because of the large number of axons in each nerve fibre. Degranulation of mast cells was not seen. These findings suggest that pruritus in lichenified atopic skin is probably not caused by damage to the cutaneous free nerve endings. In such lesions, the number of the cutaneous free nerve endings is greatly increased, but they may have a normal function.
Authors:
R Urashima; M Mihara
Related Documents :
18493787 - Hypertrophy of mature xenopus muscle fibres in culture induced by synergy of albumin an...
12693757 - Giant muscle fibres in pigs with different ryr1 genotype.
171027 - Unmyelinated fibres and schwann cells of sural nerve in neuropathy.
6195557 - Altered excitability of afferent c-fibres of the rat distal to a nerve site exposed to ...
9609807 - Effect of alae nasi activation on maximal nasal inspiratory airflow in humans.
7270927 - Morphological changes in the mechanically unloaded myocardial cell.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  432     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-12     Completed Date:  1998-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  363-70     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Faculty of Medicine, Tottori University, Nishimachi, Yonago, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Calcitonin Gene-Related Peptide / analysis
Dermatitis, Atopic / pathology*
Female
Humans
Immunohistochemistry
Male
Microscopy, Electron
Middle Aged
Nerve Tissue Proteins / analysis
Neuropeptides / analysis*
Phosphopyruvate Hydratase / analysis
Skin / chemistry,  innervation*,  pathology
Thiolester Hydrolases / analysis
Ubiquitin Thiolesterase
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptides; 83652-28-2/Calcitonin Gene-Related Peptide; EC 3.1.2.-/Thiolester Hydrolases; EC 3.1.2.15/Ubiquitin Thiolesterase; EC 4.2.1.11/Phosphopyruvate Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Thymic myoid cell turnover in myasthenia gravis patients and in normal controls.
Next Document:  Gastrin stimulates epithelial cell proliferation in the oesophagus of rats.