Document Detail


Cutaneous neoplasms in a military population of HIV-1-positive patients. Military Medical Consortium for the Advancement of Retroviral Research.
MedLine Citation:
PMID:  8349856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In HIV-1-positive patients there have been no prospective studies that show an increase in cutaneous neoplasms. OBJECTIVE: We observed HIV-1-positive patients to determine whether or not there was an increased incidence of cutaneous malignancies. METHODS: A total of 724 HIV-1-positive patients were examined during a 36-month period for the development of cutaneous malignancies. RESULTS: The most common cutaneous neoplasm found was Kaposi's sarcoma, especially in patients with late-stage disease. Basal cell carcinomas were the next most frequent tumor. We have also seen three malignant melanomas and two squamous cell carcinomas. Five patients had malignant lymphoma. One patient had a primary lymphoma of subcutaneous soft tissue; in one patient multiple cutaneous lesions developed. CONCLUSION: The distribution and prevalent types of cutaneous neoplasms in HIV-1-positive patients appear to differ from those found in other immunosuppressed populations. This may be the result of the different patterns and periods of immunosuppression in these patients and/or associated cocarcinogens to which these patients frequently are exposed.
Authors:
K J Smith; H G Skelton; J Yeager; P Angritt; K F Wagner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  29     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-09-16     Completed Date:  1993-09-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-6     Citation Subset:  IM; X    
Affiliation:
National Naval Medical Center, Department of Dermatology, Washington, D.C.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carcinoma, Basal Cell / complications,  epidemiology
Continental Population Groups
Female
HIV Seropositivity / complications*,  epidemiology
HIV-1*
Humans
Male
Melanoma / complications,  epidemiology
Middle Aged
Military Personnel*
Sarcoma, Kaposi / complications,  epidemiology
Skin Neoplasms / complications*,  epidemiology
Grant Support
ID/Acronym/Agency:
NIAMS AYO1AR90008/AR/NIAMS NIH HHS; NIAMS NYO1AR00014/AR/NIAMS NIH HHS

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