Document Detail

Cutaneous natural killer/T-cell lymphoma.
MedLine Citation:
PMID:  11862188     Owner:  NLM     Status:  MEDLINE    
Lymphomas are classified as either Hodgkin's or non-Hodgkin's. The 2 subtypes of non-Hodgkin's lymphoma that can present primarily in the skin are cutaneous T-cell lymphoma and cutaneous B-cell lymphoma, both of which tend to be low-grade malignant neoplasms. Recently another distinct subtype of lymphoma was discovered, the natural killer (NK)/T-cell lymphoma, which can involve the skin in a primary or secondary fashion. The NK/T-cell subtype of lymphoma is characterized by the expression of the NK-cell antigen CD56. These CD56(+) lymphomas are further subdivided into nasal NK/T-cell lymphomas that commonly present as midfacial destructive disease and non-nasal NK/T-cell lymphomas that often arise in extranodal locations, including the skin. We report a case of aggressive NK-cell leukemia/lymphoma with numerous secondary cutaneous lesions and review the clinical and histopathologic spectrum of non-nasal CD56(+) lymphomas, with an emphasis on the dermatologic findings.
Michael A Radonich; Rossitza Lazova; Jean Bolognia
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  46     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-25     Completed Date:  2002-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
Department of Dermatology, Yale Dermatopathology Laboratory, Yale University School of Medicine, 15 York Street, New Haven, CT 06520-8059, USA.
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MeSH Terms
Antigens, CD56 / immunology
Killer Cells, Natural / pathology*
Lymphoma, T-Cell, Cutaneous / pathology*
Skin / pathology
Skin Neoplasms / pathology*
Reg. No./Substance:
0/Antigens, CD56

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