Document Detail

Cutaneous-mucosal allergic contact reaction due to topical corticosteroids.
MedLine Citation:
PMID:  8607567     Owner:  NLM     Status:  MEDLINE    
We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler. Patch tests with a series of 25 corticosteroids, some of them at different concentrations and in different vehicles, were positive to tixocortol pivalate, hydrocortisone, budesonide, prednisolone, hydrocortisone butyrate propionate, triamcinolone acetonide, and fluocinolone acetonide. For some of them, a 1% solution in ethanol gave a positive reaction when a 20% mixture in petrolatum did not. Like other authors, we suggest that some multiple positives may represent sensitization to several steroids independently, true cross-reactions, or both, and that ethanol is a better vehicle than petrolatum.
M A Gonzalo Garijo; P Bobadilla González
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Allergy     Volume:  50     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-05-22     Completed Date:  1996-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  833-6     Citation Subset:  IM    
Allergology Department, Infanta Cristina University Hospital, Badajoz, Spain.
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MeSH Terms
Administration, Topical
Adrenal Cortex Hormones / adverse effects*
Dermatitis, Allergic Contact / etiology*
Drug Hypersensitivity / etiology*
Reg. No./Substance:
0/Adrenal Cortex Hormones

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