Document Detail

Cutaneous metastasis of an osteosarcoma. A case report.
MedLine Citation:
PMID:  8989939     Owner:  NLM     Status:  MEDLINE    
Sarcomas seldom metastasize to the skin. This report describes a rare instance of this phenomenon. A 24-year-old patient with a history of osteosarcoma (osteoblastic type) of the right humerus was seen with a cutaneous nodule on the left temple. Histologic examination of the skin showed the lesion to be a metastatic osteosarcoma. On histologic examination, a proliferation of bizarre mononucleated or multinucleated osteoblastic cells was noted in the dermis and subcutis. Although osteoid formation and calcification were not recognized, as they had been in contrast to the primary lesion, basic structures and components of the skin lesion were identical to those of the primary tumor tissue. Cutaneous metastasis from on osteosarcoma of bone is an extraordinarily rare event and, as far as we can determine, has only been reported three times.
M Setoyama; A Kanda; T Kanzaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  18     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-03     Completed Date:  1997-04-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  629-32     Citation Subset:  IM    
Department of Dermatology, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Bone Neoplasms / pathology*
Cell Division
Cell Nucleus / ultrastructure
Connective Tissue / pathology
Facial Neoplasms / pathology,  secondary
Humerus / pathology
Organelles / ultrastructure
Osteoblasts / pathology
Osteosarcoma / pathology,  secondary*
Skin / pathology
Skin Neoplasms / pathology,  secondary*

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