Document Detail

Cutaneous mercury granuloma. A clinicopathologic study and review of the literature.
MedLine Citation:
PMID:  3882785     Owner:  NLM     Status:  MEDLINE    
Cutaneous mercury granulomas are rarely encountered. Clinically they pose difficulty in diagnosis when there is no clear history of penetrating injury by objects containing metallic mercury. Histologic, chemical, and scanning electron microscopic studies of such cutaneous lesions were performed on four cases from the Armed Forces Institute of Pathology files. Reported cases from the literature were reviewed. Metallic mercury in tissue sections appears as dark, opaque globules, usually spherical in shape and of varying sizes and numbers. A zone of collagen necrosis often surrounds the mercury globules. A granulomatous foreign body-giant cell reaction and a mixed inflammatory cellular infiltrate composed of neutrophils, lymphocytes, histiocytes, plasma cells, and occasional eosinophils are usually present. Epidermal and dermal necrosis, with or without ulceration or pseudoepitheliomatous hyperplasia, is also a common finding. The gold lysis test and energy-dispersive x-ray analysis confirmed the presence of metallic mercury in the tissue. Following cutaneous injury from mercury, systemic toxicity may develop and death may even occur. An approach to clinical management is discussed.
G P Lupton; G F Kao; F B Johnson; J H Graham; E B Helwig
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  12     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-03-26     Completed Date:  1985-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-303     Citation Subset:  IM    
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MeSH Terms
Foreign-Body Reaction / pathology
Granuloma / chemically induced*,  pathology
Mercury / administration & dosage
Mercury Poisoning / etiology*
Self Administration
Skin / pathology
Skin Diseases / chemically induced*,  pathology
Reg. No./Substance:

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