Document Detail

Cutaneous manifestations of systemic lupus erythematosus in Pakistani patients.
MedLine Citation:
PMID:  14738261     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Systemic Lupus Erythematosus (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study from Karachi, Pakistan was conducted to determine the pattern and prevalence of such lesions in SLE in Pakistani patients. METHODS: One hundred ninety eight patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatology Association were examined between 1986 and 2001 for the presence of cutaneous manifestations. RESULTS: Skin changes noted were: noncicatricial diffuse alopecia (22%), malar rash (31%), mucosal lesions (20%), discoid eruptions (15%), photosensitivity (33%), vascular lesions (20%), pruritus (17%), and pigmentary changes (22%). Peripheral gangrene, chronic ulcers, Raynauds phenomenon, urticaria, chilblains, thrombophlebitis, palmar erythema, and erythema multiform were rare. Anti ANA and anti dsDNA were positive in 93% and 83% patients respectively. CONCLUSION: A different clinical pattern was noted in our patients than reported previously.
M A Rabbani; S M A Shah; A Ahmed
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  53     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-07-15     Revised Date:  2009-02-26    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  539-41     Citation Subset:  IM    
Department of Medicine, The Aga Khan University Hospital, Karachi.
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MeSH Terms
Lupus Erythematosus, Cutaneous / pathology
Lupus Erythematosus, Systemic / pathology*
Pakistan / epidemiology
Skin Diseases / epidemiology,  pathology*

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