Document Detail

Cutaneous manifestations of gastrointestinal disease: part II.
MedLine Citation:
PMID:  23317981     Owner:  NLM     Status:  MEDLINE    
The gastrointestinal (GI) and cutaneous organ systems are closely linked. In part I of this continuing medical education article, the intricacies of this relationship were explored as they pertained to hereditary polyposis disorders, hamartomatous disorders, and paraneoplastic disease. Part II focuses on the cutaneous system's links to inflammatory bowel disease and vascular disorders. An in-depth analysis of inflammatory bowel disease skin findings is provided to aid dermatologists in recognizing and facilitating early consultation and intervention by gastroenterologists. Cutaneous signs of inflammatory bowel disease include fissures and fistulae, erythema nodosum, pyoderma gangrenosum, pyostomatitis vegetans, oral aphthous ulcers, cutaneous polyarteritis nodosa, necrotizing vasculitis, and epidermolysis bullosa acquisita. Additional immune-mediated conditions, such as diverticulitis, bowel-associated dermatosis-arthritis syndrome, Henoch-Schönlein purpura, dermatitis herpetiformis, and Degos disease, in which the skin and GI system are mutually involved, will also be discussed. Genodermatoses common to both the GI tract and the skin include Hermansky-Pudlak syndrome, pseudoxanthoma elasticum, Ehlers-Danlos syndrome, hereditary hemorrhagic telangiectasia, and blue rubber bleb nevus syndrome. Kaposi sarcoma is a neoplastic disease with lesions involving both the skin and the gastrointestinal tract. Acrodermatitis enteropathica, a condition of zinc deficiency, likewise affects both the GI and dermatologic systems. These conditions are reviewed with updates on the genetic basis, diagnostic and screening modalities, and therapeutic options. Finally, GI complications associated with vascular disorders will also be discussed.
Breck Thrash; Mahir Patel; Kejal R Shah; C Richard Boland; Alan Menter
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  68     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-07     Revised Date:  2014-02-28    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211.e1-33; quiz 244-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Acrodermatitis / complications,  diagnosis
Colitis, Ulcerative / complications
Crohn Disease / complications
Dermatitis Herpetiformis / complications,  diagnosis
Ehlers-Danlos Syndrome / complications
Gastrointestinal Diseases / complications*
Gastrointestinal Neoplasms / diagnosis
Hermanski-Pudlak Syndrome / complications
Inflammatory Bowel Diseases / complications
Malignant Atrophic Papulosis / diagnosis
Nevus, Blue / diagnosis
Pseudoxanthoma Elasticum / complications
Purpura, Schoenlein-Henoch / complications,  immunology
Skin Diseases / etiology*,  pathology
Skin Neoplasms / diagnosis
Telangiectasia, Hereditary Hemorrhagic / diagnosis
Zinc / deficiency
Reg. No./Substance:
Comment In:
J Am Acad Dermatol. 2014 Feb;70(2):385   [PMID:  24438959 ]
J Am Acad Dermatol. 2014 Feb;70(2):385   [PMID:  24438957 ]

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