| Cutaneous lesions as initial signs of interferon alpha-induced sarcoidosis: report of three new cases and review of the literature. | |
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MedLine Citation:
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PMID: 19891685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sarcoid reactions are well-recognized adverse events during interferon (IFN) therapy. They are frequently underdiagnosed because misinterpreted as IFN-induced side effects. Sarcoid cutaneous lesions may therefore represent useful hints to an early diagnosis, but their incidence is unknown. We report three new cases of mono-localized, purely cutaneous IFNalpha-induced sarcoidosis. In addition, an extensive review of the literature, with special attention to skin involvement, was performed through a PubMed search. The analysis of the retrieved articles showed that cutaneous lesions are frequent signs of IFN-induced sarcoidosis. Skin involvement is documented in 56% of the reports and it appears among the presenting and diagnostic signs of a sarcoid reaction in 51%. Special attention to dermatologic signs is imperative in the course of IFN therapy because even minimal skin involvement may offer a clue to an early diagnosis of IFN-induced sarcoidosis. |
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Authors:
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Fabrizio Fantini; Claudia Padalino; Giulio Gualdi; Paola Monari; Alberto Giannetti |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Dermatologic therapy Volume: 22 Suppl 1 ISSN: 1529-8019 ISO Abbreviation: Dermatol Ther Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-06 Completed Date: 2010-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9700070 Medline TA: Dermatol Ther Country: Denmark |
Other Details:
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Languages: eng Pagination: S1-7 Citation Subset: IM |
Affiliation:
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Clinica Dermatologica, Universit?? degli Studi di Modena e Reggio Emilia, Modena, Italy. fantini.fabrizio@unimore.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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adverse effects* Drug Eruptions / pathology* Female Hepatitis C, Chronic / drug therapy* Humans Interferon-alpha / adverse effects* Middle Aged Sarcoidosis / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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