Document Detail

Cutaneous lesions as initial signs of interferon alpha-induced sarcoidosis: report of three new cases and review of the literature.
MedLine Citation:
PMID:  19891685     Owner:  NLM     Status:  MEDLINE    
Sarcoid reactions are well-recognized adverse events during interferon (IFN) therapy. They are frequently underdiagnosed because misinterpreted as IFN-induced side effects. Sarcoid cutaneous lesions may therefore represent useful hints to an early diagnosis, but their incidence is unknown. We report three new cases of mono-localized, purely cutaneous IFNalpha-induced sarcoidosis. In addition, an extensive review of the literature, with special attention to skin involvement, was performed through a PubMed search. The analysis of the retrieved articles showed that cutaneous lesions are frequent signs of IFN-induced sarcoidosis. Skin involvement is documented in 56% of the reports and it appears among the presenting and diagnostic signs of a sarcoid reaction in 51%. Special attention to dermatologic signs is imperative in the course of IFN therapy because even minimal skin involvement may offer a clue to an early diagnosis of IFN-induced sarcoidosis.
Fabrizio Fantini; Claudia Padalino; Giulio Gualdi; Paola Monari; Alberto Giannetti
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Dermatologic therapy     Volume:  22 Suppl 1     ISSN:  1529-8019     ISO Abbreviation:  Dermatol Ther     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  S1-7     Citation Subset:  IM    
Clinica Dermatologica, Universit?? degli Studi di Modena e Reggio Emilia, Modena, Italy.
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MeSH Terms
Antiviral Agents / adverse effects*
Drug Eruptions / pathology*
Hepatitis C, Chronic / drug therapy*
Interferon-alpha / adverse effects*
Middle Aged
Sarcoidosis / chemically induced*,  pathology
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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