Document Detail

Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies.
MedLine Citation:
PMID:  10069884     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies defining the histopathologic features of patients with chronic idiopathic urticaria (CIU) were performed on wheals of uncertain duration and before the identification of functional autoantibodies against FcepsilonRI and/or IgE, now known to be present in approximately 30% of patients with CIU.
OBJECTIVE: We sought to determine the timing of the inflammatory infiltrate in the wheals of patients with CIU and to detect differences between patients with and without autoantibodies.
METHODS: Immunohistochemistry was used to identify neutrophils (neutrophil elastase), T lymphocytes (CD3), and activated eosinophils (EG2) in biopsy specimens from uninvolved skin and wheals present for less than 4 hours and greater than 12 hours in 22 patients with CIU, as well as in biopsy specimens from the skin of 12 healthy control subjects. Patients were identified as having functional autoantibodies on the basis of their serum-evoked histamine release in vitro from the basophils of 2 healthy donors.
RESULTS: EG2(+), neutrophil elastase+, and, to a lesser extent, CD3(+) cells were found in greater numbers in wheals undergoing biopsy at less than 4 and greater than 12 hours than in uninvolved skin (P <.05). Patients without autoantibodies (n = 12) had significantly more EG2(+) cells in wheals of greater than 12 hours' duration than patients with autoantibodies (n = 10; P =.02). There was no other difference between patients with and without autoantibodies in the cutaneous cellular infiltrate.
CONCLUSION: Neutrophil and eosinophil accumulation occurs early in the evolution of a wheal in patients with CIU, but eosinophil activation may occur later or be more persistent in patients without autoantibodies.
R A Sabroe; E Poon; G E Orchard; D Lane; D M Francis; R M Barr; M M Black; A K Black; M W Greaves
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  103     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-02     Completed Date:  1999-04-02     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  484-93     Citation Subset:  AIM; IM    
Professorial Unit, St John's Institute of Dermatology, Guy's, King's College and St Thomas's Hospitals' Medical and Dental Schools, St Thomas's Hospital, London, United Kingdom.
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MeSH Terms
Antibodies, Anti-Idiotypic / blood*,  immunology
Antigens, CD3 / analysis
Autoantibodies / blood*,  immunology
Autoimmune Diseases / immunology,  pathology*
Biological Markers
Chronic Disease
Eosinophils / pathology*
Histamine Release
Immunoglobulin E / immunology*
Leukocyte Elastase / analysis
Middle Aged
Neutrophils / pathology*
Receptors, IgE / immunology*
T-Lymphocytes / pathology*
Urticaria / immunology,  pathology*
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Antigens, CD3; 0/Autoantibodies; 0/Biological Markers; 0/Receptors, IgE; 0/anti-IgE antibodies; 37341-29-0/Immunoglobulin E; EC Elastase

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