| Cutaneous infiltrates and peripheral blood immune responses in dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis. | |
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MedLine Citation:
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PMID: 20015110 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study characterizes T- and B-lymphocyte responses in the peripheral blood and lesional skin of dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis (ImR-LPP), a term previously proposed to denote a subpopulation of dogs with idiopathic pododermatitis. T-cell (CD3(+) , CD4(+) and CD8(+) ) and B-cell (CD21(+) ) counts were significantly increased in both the epidermis and dermis of lesional ImR-LPP skin compared with that in pedal skin from healthy controls. CD3(+) , CD4(+) , CD8(+) and CD21(+) cells were commonly observed in perivascular sites in the superficial dermis, periadnexally, beneath the dermal-epidermal (DE) junction and in the epidermis of lesional ImR-LPP skin. The CD8(+) /CD3(+) T-cell ratio in peripheral blood was significantly increased in the ImR-LPP group (0.42 versus 0.35 in controls). Serum IgA, IgG and IgM concentrations were all significantly elevated in affected dogs. Lymphocyte stimulation indices in ImR-LPP dogs were comparable with control levels except for a lower response to ionomycin (6.0 versus 11.1). Dogs with ImR-LPP had a higher incidence and mean (semi-quantitative) score for IgA, IgG and IgM deposits in the epidermis, and a significantly increased incidence of dermal IgA(+) , IgG(+) and IgM(+) mononuclear inflammatory cells. The results indicate that upregulated T- and B-lymphocyte responses may contribute to the pathogenesis of the skin lesions observed in dogs with ImR-LPP. |
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Authors:
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Rory M Breathnach; Shay Fanning; Grace Mulcahy; Hugh F Bassett; Eric Strobl; Boyd R Jones |
Publication Detail:
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Type: Journal Article Date: 2009-12-14 |
Journal Detail:
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Title: Veterinary dermatology Volume: 21 ISSN: 1365-3164 ISO Abbreviation: Vet. Dermatol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2012-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426187 Medline TA: Vet Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 383-92 Citation Subset: IM |
Copyright Information:
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© 2009 The Authors. Journal compilation © 2009 ESVD and ACVD. |
Affiliation:
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School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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