Document Detail


Cutaneous infiltrates and peripheral blood immune responses in dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis.
MedLine Citation:
PMID:  20015110     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This study characterizes T- and B-lymphocyte responses in the peripheral blood and lesional skin of dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis (ImR-LPP), a term previously proposed to denote a subpopulation of dogs with idiopathic pododermatitis. T-cell (CD3(+) , CD4(+) and CD8(+) ) and B-cell (CD21(+) ) counts were significantly increased in both the epidermis and dermis of lesional ImR-LPP skin compared with that in pedal skin from healthy controls. CD3(+) , CD4(+) , CD8(+) and CD21(+) cells were commonly observed in perivascular sites in the superficial dermis, periadnexally, beneath the dermal-epidermal (DE) junction and in the epidermis of lesional ImR-LPP skin. The CD8(+) /CD3(+) T-cell ratio in peripheral blood was significantly increased in the ImR-LPP group (0.42 versus 0.35 in controls). Serum IgA, IgG and IgM concentrations were all significantly elevated in affected dogs. Lymphocyte stimulation indices in ImR-LPP dogs were comparable with control levels except for a lower response to ionomycin (6.0 versus 11.1). Dogs with ImR-LPP had a higher incidence and mean (semi-quantitative) score for IgA, IgG and IgM deposits in the epidermis, and a significantly increased incidence of dermal IgA(+) , IgG(+) and IgM(+) mononuclear inflammatory cells. The results indicate that upregulated T- and B-lymphocyte responses may contribute to the pathogenesis of the skin lesions observed in dogs with ImR-LPP.
Authors:
Rory M Breathnach; Shay Fanning; Grace Mulcahy; Hugh F Bassett; Eric Strobl; Boyd R Jones
Publication Detail:
Type:  Journal Article     Date:  2009-12-14
Journal Detail:
Title:  Veterinary dermatology     Volume:  21     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2012-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  383-92     Citation Subset:  IM    
Copyright Information:
© 2009 The Authors. Journal compilation © 2009 ESVD and ACVD.
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
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