Document Detail

Cutaneous immunofluorescence study of erythema multiforme: correlation with light microscopic patterns and etiologic agents.
MedLine Citation:
PMID:  6373850     Owner:  NLM     Status:  MEDLINE    
Direct immunofluorescence microscopy was positive in 88% of forty-one skin biopsy specimens from thirty-four patients with the clinical diagnosis of erythema multiforme. The most common finding, present in 67% of positive specimens, was the cytoid body, or fluorescent keratinocyte, which stained most often with IgM (homogeneously) or with C3 (speckled). Other findings included basement membrane zone (BMZ) fluorescence, primarily with fibrinogen and C3, and vascular fluorescence, most commonly C3 in a granular pattern. Correlation of direct immunofluorescent and light microscopic findings revealed that (1) the fluorescent keratinocyte was prevalent only in epidermal and mixed patterns, correlating with the eosinophilic necrotic keratinocyte by light microscopy, and (2) vascular fluorescence was most prominent in dermal forms. Herpes simplex-associated erythema multiforme showed exclusively a mixed histologic pattern, whereas the drug-related form was primarily epidermal.
M C Finan; A L Schroeter
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  10     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-07-12     Completed Date:  1984-07-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  497-506     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / adverse effects
Basement Membrane / blood supply,  immunology,  pathology
Blood Vessels / immunology,  pathology
Child, Preschool
Complement C3 / analysis
Epidermis / immunology,  pathology
Erythema Multiforme / etiology,  immunology*,  pathology
Fibrinogen / analysis
Fluorescent Antibody Technique
Herpes Simplex / complications
Immunoglobulin M / analysis
Middle Aged
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Complement C3; 0/Immunoglobulin M; 9001-32-5/Fibrinogen

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