Document Detail

Cutaneous hypersensitivity to Malassezia sympodialis and dust mite in adult atopic dermatitis with a textile pattern.
MedLine Citation:
PMID:  16487281     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (AD) patients with predominantly head and neck involvement react to patch tests of the yeast Malassezia sympodialis (Ms). Protein patch testing methods and interpretation are controversial, but subgroups of AD patients may have unique triggers for disease activity. The aim of the study was to identify clinical characteristics of patients who are patch test-positive to Dermatophagoides farinae/pteronyssinus (Df) and Ms and characterize cutaneous cytokine profiles of the atopy patch tests (APTs). 25 AD patients and 27 control dermatitis patients were patch tested with Ms and Df. Qualitative analysis of Th-1 and Th-2 cytokines by RT-PCR mRNA was obtained from positive APTs. Atopic dermatitis patients with a textile pattern or head and neck involvement demonstrated more positive APTs to Ms than control patients. Early positive APTs (<6 hr) did not exhibit a Th-1 type cytokine profile. The subgroup of adult AD patients with head, neck and upper torso pattern of dermatitis seems most likely to react to Ms (and Df). The immune mechanism of protein patch tests includes a Th-1 cell-mediated component after 6 hr or more.
Haydee M Ramirez de Knott; Thomas S McCormick; Katrin Kalka; George Skandamis; Mahmoud A Ghannoum; Mark Schluchter; Kevin D Cooper; Susan T Nedorost
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  54     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-06-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  92-9     Citation Subset:  IM    
Department of Dermatology, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA.
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MeSH Terms
Aged, 80 and over
Allergens / diagnostic use,  immunology*
Antigens, Dermatophagoides / diagnostic use,  immunology
Case-Control Studies
Dermatitis, Allergic Contact / diagnosis*,  etiology,  immunology,  pathology
Dermatitis, Atopic / diagnosis*,  etiology,  immunology,  pathology
Malassezia / immunology*
Middle Aged
Patch Tests
Pyroglyphidae / immunology*
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction
Th1 Cells / immunology
Th2 Cells / immunology
Grant Support
Reg. No./Substance:
0/Allergens; 0/Antigens, Dermatophagoides; 0/RNA, Messenger

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