| Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. | |
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MedLine Citation:
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PMID: 2812853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The flexion reflex threshold has been used as a measure of sensation in a group of premature infants born at 27-32 weeks postmenstrual age. The threshold in an area of local tissue damage created by routine heel lances was half the threshold on the intact heel on the other side. This indicated a hypersensitivity to tissue damage analogous to tenderness or hyperalgesia reported in adults. In a double-blind study, treatment of the damaged area with the topical anaesthetic cream, EMLA, was found to reverse this hypersensitivity or in other words increase the flexion reflex threshold. Treatment with placebo had no effect. The results show that the newborn infant central nervous system is capable of mounting a chronic pain response to local injury which can be reduced by local anaesthetic. |
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Authors:
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M Fitzgerald; C Millard; N McIntosh |
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3818163 - Injury mortality and socioeconomic development: an exploratory analysis. 18230283 - Road crash in china from 2003 to 2005. 12452503 - Risk factors for hospital-acquired infections in the neonatal intensive care unit. |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pain Volume: 39 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-12-08 Completed Date: 1989-12-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 31-6 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Developmental Biology, University College London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Local
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therapeutic use* Ankle Injuries* Blood Specimen Collection / adverse effects, methods Double-Blind Method Drug Combinations / therapeutic use Female Humans Hypersensitivity / drug therapy, etiology*, physiopathology Infant, Newborn Lidocaine / therapeutic use* Longitudinal Studies Male Prilocaine / therapeutic use* Reflex / physiology Sensory Thresholds / drug effects Skin Diseases / drug therapy, etiology*, physiopathology Wounds, Penetrating / complications |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 137-58-6/Lidocaine; 721-50-6/Prilocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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