Document Detail

Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia.
MedLine Citation:
PMID:  2812853     Owner:  NLM     Status:  MEDLINE    
The flexion reflex threshold has been used as a measure of sensation in a group of premature infants born at 27-32 weeks postmenstrual age. The threshold in an area of local tissue damage created by routine heel lances was half the threshold on the intact heel on the other side. This indicated a hypersensitivity to tissue damage analogous to tenderness or hyperalgesia reported in adults. In a double-blind study, treatment of the damaged area with the topical anaesthetic cream, EMLA, was found to reverse this hypersensitivity or in other words increase the flexion reflex threshold. Treatment with placebo had no effect. The results show that the newborn infant central nervous system is capable of mounting a chronic pain response to local injury which can be reduced by local anaesthetic.
M Fitzgerald; C Millard; N McIntosh
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pain     Volume:  39     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-08     Completed Date:  1989-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Department of Anatomy and Developmental Biology, University College London, U.K.
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MeSH Terms
Anesthetics, Local / therapeutic use*
Ankle Injuries*
Blood Specimen Collection / adverse effects,  methods
Double-Blind Method
Drug Combinations / therapeutic use
Hypersensitivity / drug therapy,  etiology*,  physiopathology
Infant, Newborn
Lidocaine / therapeutic use*
Longitudinal Studies
Prilocaine / therapeutic use*
Reflex / physiology
Sensory Thresholds / drug effects
Skin Diseases / drug therapy,  etiology*,  physiopathology
Wounds, Penetrating / complications
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 137-58-6/Lidocaine; 721-50-6/Prilocaine

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