Document Detail


Cutaneous human papillomavirus 88: remarkable differences in viral load.
MedLine Citation:
PMID:  17935140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79 actinic keratoses, 73 seborrhoeic keratoses, 169 basal cell carcinomas and 126 SCCs) and 362 healthy skin biopsies found detectable HPV88 DNA in only 7 specimens. All these had very low viral loads (<1 copy/10(3) cells) implying extreme biological variability in viral load.
Authors:
Johanna Kullander; Alessandra Handisurya; Ola Forslund; Alexandra Geusau; Reinhard Kirnbauer; Joakim Dillner
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  122     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-27     Completed Date:  2008-01-08     Revised Date:  2014-01-01    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  477-80     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biopsy
Carcinoma, Basal Cell / virology*
Carcinoma, Squamous Cell / virology*
Humans
Keratosis / virology*
Male
Middle Aged
Papillomaviridae / metabolism*
Papillomavirus Infections / diagnosis,  virology*
Reverse Transcriptase Polymerase Chain Reaction
Skin / metabolism
Skin Neoplasms / pathology*,  virology*
Viral Load
Grant Support
ID/Acronym/Agency:
P 18990-B13//Austrian Science Fund FWF
Comments/Corrections

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