Document Detail

Cutaneous epithelioid angiomatous nodule arising in capillary malformation.
MedLine Citation:
PMID:  20602659     Owner:  NLM     Status:  In-Data-Review    
Cutaneous epithelioid angiomatous nodule (CEAN) represents a rare, benign vascular lesion described by Brenn and Fletcher in 2004. To the best of our knowledge, the development of CEAN in a pre-existing vascular malformation has not been previously reported. A 52-year-old Japanese woman presented with multiple erythematous papules developed on violaceous macule of the right back that had been diagnosed as capillary malformation (CM) in childhood. Histopathological examination of one erythematous papule revealed a relatively well-circumscribed nodule composed mostly of epithelioid cells in the dermis. Abnormal dilated vessels were also identified around the lesion in the dermis, suggesting a CM. Immunohistochemically, the epithelioid cells were positive for CD31 and CD34. Staining for α-smooth muscle actin highlighted pericytes with epithelioid features. These findings were consistent with a diagnosis of CEAN arising in CM. The excised specimens of other erythematous papules revealed pyogenic granuloma (PyG) with focal epithelioid morphology accompanied by CM. We present the first reported case of CEAN arising in CM. Considering the histopathological findings, we speculate that CEAN of our case could be associated with PyG developed in pre-existing CM, and may thus be a variant of PyG with a mostly epithelioid appearance. Shiomi T, Kaddu S, Yoshida Y, Yamamoto O, Yamane T, Shomori K, Ito H. Cutaneous epithelioid angiomatous nodule arising in capillary malformation.
Tatsushi Shiomi; Steven Kaddu; Yuichi Yoshida; Osamu Yamamoto; Tetsumi Yamane; Kohei Shomori; Hisao Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  38     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  372-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons A/S.
Department of Organ Pathology Department of Dermatology, Tottori University, Faculty of Medicine, Yonago, Japan Department of Dermatology, Medical University of Graz, Austria Departments of Clinical Laboratory and Diagnostic Pathology, Tottori Red Cross Hospital, Tottori, Japan.
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