Document Detail

Cutaneous elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
MedLine Citation:
PMID:  11899147     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: After exposure, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is excreted via the faeces, breast milk and epidermal lipids. OBJECTIVES: To determine to what extent TCDD is eliminated via the skin and to evaluate whethe cutaneous elimination can be accelerated by the application of petrolatum. METHODS: In two patients severely intoxicated with TCDD, material obtained from the skin surface and, in one patient, cerumen and the content of epithelial cysts, was analysed for TCDD. RESULTS: The TCDD concentration in the initial blood sample taken was 144 000 pg g(-1) blood fa in patient 1, and 26 000 pg g(-1) blood fat in patient 2. Six months later, when the skin tests were performed, the blood TCDD levels had decreased to 80 900 and 16 100 pg g(-1) blood fat, respectively. In the two samples of pooled cyst contents from patient 1, TCDD levels of 34 400 an 18 600 pg g(-1) fat were found. A cerumen sample contained TCDD at 20 500 pg g(-1) fat. In the material collected from the skin surface we observed a linear increase of the amount of TCD measured per test field with time, indicating a continuous elimination of TCDD via the skin. Th daily amount of TCDD eliminated via the skin was 1.51 pg cm(-2) in patient 1 and 0.57 pg cm(-2) in patient 2. Application of petrolatum led to a twofold increase in the amount of TCDD measured in patient 1, but had no significant effect in patient 2. CONCLUSIONS: In our patients, elimination of TCDD via the skin, most probably through desquamating scales, represented 1-2% of the overall daily TCDD elimination rate, with regard to the body surface and when calculated on the basis of the half-life of TCDD at the time of the skin test. If a more typical overall elimination half-life of 7 years is used as the basis for the calculatio the skin would account for 9% (patient 1) and 15% (patient 2) of the overall elimination. Although we observed an increase in TCDD in material derived from the skin surface of up to 100% after application of petrolatum in patient 1, such an approach appears not to be a feasible means to increase elimination. Owing to the small amount of TCDD measured in skin-surface material, as well as in the cyst contents and cerumen obtained from one patient, contamination of the environment and other persons appears highly unlikely.
A Geusau; E Tschachler; M Meixner; O Päpke; G Stingl; M McLachlan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  145     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  938-43     Citation Subset:  IM    
Department of Dermatology, Allergy and Infectious Diseases, University of Vienna Medical School, Austria.
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MeSH Terms
Acne Vulgaris / chemically induced*,  metabolism
Cerumen / metabolism
Emollients / pharmacology
Environmental Pollutants / blood,  pharmacokinetics*,  poisoning
Follow-Up Studies
Metabolic Detoxication, Drug
Petrolatum / pharmacology
Skin / drug effects,  metabolism*
Teratogens / pharmacokinetics*
Tetrachlorodibenzodioxin / blood,  pharmacokinetics*,  poisoning
Reg. No./Substance:
0/Emollients; 0/Environmental Pollutants; 0/Teratogens; 1746-01-6/Tetrachlorodibenzodioxin; 8009-03-8/Petrolatum

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