Document Detail

Cutaneous basophil hypersensitivity.
MedLine Citation:
PMID:  783235     Owner:  NLM     Status:  MEDLINE    
Cutaneous basophil hypersensitivity (CBH) is a distinct form of lymphocyte-mediated hypersensitivity in guinea pigs, separate both from classic delayed hypersensitivity (DH) and from the well-known antibody-mediated reactions. CBH, not DH, is the usual cellular immune response of this species to a wide variety of immunogens (e.g., allografts, certain parasites, and viruses) when these are presented in native form without supplementation with mycobacteria-containing adjuvants, thus attesting to the importance of this response in the guinea pig's overall immune defense mechanism. Basophil-containing, cell-mediated, delayed-onset reactions occur in other species, including man, as well.
H F Dvorak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  58     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-40     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Specificity
Basophils / immunology*
Capillary Permeability
Fibrin / metabolism
Guinea Pigs
Hypersensitivity, Delayed / immunology*,  pathology
Immunity, Cellular*
Immunization, Passive
Lymphocytes / immunology
Mast Cells / immunology
Organ Specificity
Species Specificity
Reg. No./Substance:

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