Document Detail


Cutaneous alpha, beta and gamma human papillomaviruses in relation to squamous cell carcinoma of the skin: a population-based study.
MedLine Citation:
PMID:  23536363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human papillomavirus (HPV) infection is common worldwide and, in immunodeficient populations, may contribute to the pathogenesis of keratinocyte cancers, particularly squamous cell carcinomas (SCC). However, their role in SCC in the general population is less clear. We conducted a comprehensive analysis to investigate the independent effects of seropositivity for cutaneous alpha, beta and gamma HPV types on risk of SCC, and a meta-analysis of the available literature. In a population-based case-control study from New Hampshire, USA (n = 1,408), histologically confirmed SCC cases and controls were tested for L1 antibodies to alpha, beta and gamma cutaneous HPV types 2-5, 7-10, 15, 17, 20, 23, 24, 27b, 36, 38, 48-50, 57, 65, 75-77, 88, 92, 95, 96, 101, 103 and 107 using multiplex serology. An increasing risk of SCC with number of beta HPVs to which an individual tested positive was observed even among those seronegative for gamma types (p for trend = 0.016) with an odds ratio of 1.95 (95% confidence interval (CI) = 1.07-3.56) for four or more beta types positive. In a meta-analysis of six case-control studies, increased SCC risks in relation to beta HPV seropositivity were found across studies (meta odds ratio = 1.45, CI = 1.27-1.66). While the prevalence of gamma HPVs assayed was somewhat higher among SCC cases than controls, the association was only weakly evident among those seronegative for beta HPVs. Overall, the association between cutaneous HPVs and skin cancers appears to be specific to SCC and to genus beta HPVs in a general US population.
Authors:
Shohreh F Farzan; Tim Waterboer; Jiang Gui; Heather H Nelson; Zhongze Li; Kristina M Michael; Ann E Perry; Steven K Spencer; Eugene Demidenko; Adele C Green; Michael Pawlita; Margaret R Karagas
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural     Date:  2013-04-22
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  133     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-07-15     Completed Date:  2013-09-23     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1713-20     Citation Subset:  IM    
Copyright Information:
© 2013 UICC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alphapapillomavirus
Betapapillomavirus
Carcinoma, Squamous Cell* / epidemiology,  etiology,  virology
Case-Control Studies
Cohort Studies
Female
Gammapapillomavirus
Humans
Male
Middle Aged
Papillomavirus Infections / epidemiology*
Prevalence
Risk Factors
Skin / virology
Skin Neoplasms* / epidemiology,  etiology,  virology
United States
Grant Support
ID/Acronym/Agency:
CA118443/CA/NCI NIH HHS; CA57494/CA/NCI NIH HHS; G0802468//Medical Research Council; P30 CA023108/CA/NCI NIH HHS; R01 CA057494/CA/NCI NIH HHS; R01 CA118443/CA/NCI NIH HHS
Comments/Corrections

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