| Cutaneous sarcoidosis. | |
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MedLine Citation:
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PMID: 20665394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sarcoidosis is a systemic disease with skin manifestations. Skin manifestations are classified as nonspecific if they are not characterized by granulomatous inflammation and specific if the lesions have granulomas histologically. Erythema nodosum is the most common nonspecific skin manifestation, and it portends a good prognosis. Specific skin lesions have a varied clinical appearance, although often they can be distinguished by their yellow translucent character. Despite the potential variable appearance, there are common clinical presentations. Lupus pernio lesions are nodular violaceous specific skin lesions found predominantly on the face associated with scarring and a poor prognosis. Treatment of cutaneous sarcoidosis is primarily done to avoid scarring and cosmetic disfigurement. Local and systemic corticosteroids are the mainstay of treatment for the disease. Corticosteroid-sparing agents used to manage the disease include antimalarials, methotrexate, and tetracycline antibiotics. Tumor necrosis factor-alpha (TNF-alpha) antagonists such as infliximab may have a role in cutaneous sarcoidosis, especially in refractory cases that are resistant to the standard regimens. |
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Authors:
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Richard M Marchell; Marc A Judson |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-07-27 |
Journal Detail:
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Title: Seminars in respiratory and critical care medicine Volume: 31 ISSN: 1098-9048 ISO Abbreviation: Semin Respir Crit Care Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431858 Medline TA: Semin Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 442-51 Citation Subset: IM |
Copyright Information:
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Copyright Thieme Medical Publishers. |
Affiliation:
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Department of Dermatology, Medical University of South Carolina, Charleston, SC 29425, USA. marchell@musc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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therapeutic use Dermatologic Agents / therapeutic use Erythema Nodosum / etiology, pathology, therapy* Glucocorticoids / therapeutic use Humans Prognosis Sarcoidosis / pathology, therapy* Skin Diseases / etiology, pathology, therapy* Tumor Necrosis Factor-alpha / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Dermatologic Agents; 0/Glucocorticoids; 0/Tumor Necrosis Factor-alpha; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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