Document Detail


Cutaneous sarcoidosis.
MedLine Citation:
PMID:  20665394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sarcoidosis is a systemic disease with skin manifestations. Skin manifestations are classified as nonspecific if they are not characterized by granulomatous inflammation and specific if the lesions have granulomas histologically. Erythema nodosum is the most common nonspecific skin manifestation, and it portends a good prognosis. Specific skin lesions have a varied clinical appearance, although often they can be distinguished by their yellow translucent character. Despite the potential variable appearance, there are common clinical presentations. Lupus pernio lesions are nodular violaceous specific skin lesions found predominantly on the face associated with scarring and a poor prognosis. Treatment of cutaneous sarcoidosis is primarily done to avoid scarring and cosmetic disfigurement. Local and systemic corticosteroids are the mainstay of treatment for the disease. Corticosteroid-sparing agents used to manage the disease include antimalarials, methotrexate, and tetracycline antibiotics. Tumor necrosis factor-alpha (TNF-alpha) antagonists such as infliximab may have a role in cutaneous sarcoidosis, especially in refractory cases that are resistant to the standard regimens.
Authors:
Richard M Marchell; Marc A Judson
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-27
Journal Detail:
Title:  Seminars in respiratory and critical care medicine     Volume:  31     ISSN:  1098-9048     ISO Abbreviation:  Semin Respir Crit Care Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431858     Medline TA:  Semin Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-51     Citation Subset:  IM    
Copyright Information:
Copyright Thieme Medical Publishers.
Affiliation:
Department of Dermatology, Medical University of South Carolina, Charleston, SC 29425, USA. marchell@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / therapeutic use
Dermatologic Agents / therapeutic use
Erythema Nodosum / etiology,  pathology,  therapy*
Glucocorticoids / therapeutic use
Humans
Prognosis
Sarcoidosis / pathology,  therapy*
Skin Diseases / etiology,  pathology,  therapy*
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Dermatologic Agents; 0/Glucocorticoids; 0/Tumor Necrosis Factor-alpha; 0/infliximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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