Document Detail


Cutaneous Sarcoidosis: An Uncommon Side Effect of Pegylated Interferon and Ribavirin Use for Chronic Hepatitis C.
MedLine Citation:
PMID:  21103255     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The treatment of chronic hepatitis C (CHC) has evolved in the past 15 years and combination of pegylated interferon plus ribavirin is its current standard therapy. However, several side effects are commonly observed and frequently lead to transient or definitive interruption of treatment. Although sarcoidosis in its systemic or cutaneous form is a very rare side effect in such circumstances, some cases have been reported even with conventional interferon. This brief review of the literature and description of a case of sarcoidosis occurring in a tattoo and a scar patient's face, during treatment with pegylated interferon alpha-2b plus ribavirin, is an educative report directed in special to dermatologists. The lesion improved after drug interruption and recurred after retreatment with pegylated interferon alpha-2a. We conclude that this side effect must call the attention of doctors to seek for the diagnosis and therapy as soon as possible in such circumstances. No differences were noticed neither with alpha-2a nor alpha-2b pegylated interferon employment.
Authors:
Elson Vidal Martins; Ana Karla Gaburri; Debora Gaburri; Angelo Sementilli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-11-21
Journal Detail:
Title:  Case reports in gastroenterology     Volume:  3     ISSN:  1662-0631     ISO Abbreviation:  Case Rep Gastroenterol     Publication Date:  2009  
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474819     Medline TA:  Case Rep Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  366-371     Citation Subset:  -    
Affiliation:
Department of Gastroenterology and Hepatology, Metropolitan University of Santos, Santos, Brazil.
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