| Cutaneous metastases: a study of 78 biopsies from 69 patients. | |
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MedLine Citation:
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PMID: 20051816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective study of all cases of cutaneous metastases received in the Department of Pathology during the last 13 years was performed. Seventy-eight cases from 69 patients were examined. The majority of the patients were between 60 and 80 years of age. The most frequent anatomical location for the metastases was the abdomen. Regarding the primary tumor, breast carcinoma was the most common. In females breast carcinoma was the most common, while lymphomas predominated in males. In 14 patients (17.95%), the origin of the primary tumor was unknown. In all these cases, there was no clinical suspicion of metastasis. Epidermotropism was found in only 9 out of 78 cases (11.54%). Contrary to this, vascular invasion was a common feature, being present in 49 out of 78 cases (62.82%). Necrosis was evident in 38 cases (48.72%), but it was either moderate or prominent only in 8 cases (10.26%). Inflammatory infiltrate was absent in 3 cases (3.85%), mild in 49 (62.82%), moderate in 20 (25.64%), and prominent (graded either 3 of 4 or 4 out of 4) in 5 cases (6.41%). The metastases involved exclusively the dermis in 26 cases (33.33%), hypodermis in 7 cases (8.97%), and dermis and hypodermis in 44 cases (56.41%). We concluded that vascular invasion is a common feature in cutaneous metastases, especially in nonhematologic neoplasms, and because sometimes is focal, it should be carefully searched. |
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Authors:
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Angel Fernandez-Flores |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 32 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 222-39 Citation Subset: IM |
Affiliation:
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Service of Anatomic Pathology, Hospital El Bierzo, Ponferrada, Spain. gpyauflowerlion@terra.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Adult Aged Aged, 80 and over Biopsy Breast Neoplasms / chemistry, pathology Female Humans Immunohistochemistry Lymphoma / chemistry, pathology Male Middle Aged Necrosis Neoplasm Invasiveness / pathology Neoplasms, Unknown Primary / chemistry, pathology Retrospective Studies Skin Neoplasms / chemistry, secondary* Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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