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Cutaneous Changes: An Initial Manifestation of Pulmonary Wegener's Granulomatosis.
MedLine Citation:
PMID:  22826081     Owner:  NLM     Status:  Publisher    
Cutaneous vasculitis can occur as an isolated dermatologic disorder or as manifestation of a potentially life-threatening systemic vasculitis such as Wegener's granulomatosis (WG). The aim of the study was to characterize cutaneous lesions in 66 WG patients (30 female, 36 male) and to assess the viability of skin biopsy the diagnosis of WG. Skin involvement was observed in 21 (32%) WG patients; in 14 (21%) patients as an initial manifestation and in other seve=4), hemorrhagic bullae (n=3), ulcers (n=2), pustules (n=1), pyoderma gangrenosum (n =1). The patient with pulmonary WG can present initially with cutaneous symptoms and positive PR3-ANCA serologic test results. Leukocytoclastic vasculitis (LCV) was the predominant histopathologic pattern.
Katarzyna Zycinska; Kazimierz Wardyn; Tadeusz M Zielonka; Aneta Nitsch-Osuch; Roman Smolarczyk
Publication Detail:
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  755     ISSN:  0065-2598     ISO Abbreviation:  -     Publication Date:  2013  
Date Detail:
Created Date:  2012-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  307-310     Citation Subset:  -    
Department of Family Medicine, Internal and Metabolic Diseases Warsaw Medical University, Banacha 1a st., 02-097, Warsaw, Poland,
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