Document Detail

Customised birthweight standards accurately predict perinatal morbidity.
MedLine Citation:
PMID:  17251224     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Fetal growth restriction is associated with adverse perinatal outcome but is often not recognised antenatally, and low birthweight centiles based on population norms are used as a proxy instead. This study compared the association between neonatal morbidity and fetal growth status at birth as determined by customised birthweight centiles and currently used centiles based on population standards.
DESIGN: Retrospective cohort study.
SETTING: Referral hospital, Barcelona, Spain.
PATIENTS: A cohort of 13 661 non-malformed singleton deliveries.
INTERVENTIONS: Both population-based and customised standards for birth weight were applied to the study cohort. Customised weight centiles were calculated by adjusting for maternal height, booking weight, parity, ethnic origin, gestational age at delivery and fetal sex.
MAIN OUTCOME MEASURES: Newborn morbidity and perinatal death.
RESULTS: The association between smallness for gestational age (SGA) and perinatal morbidity was stronger when birthweight limits were customised, and resulted in an additional 4.1% (n=565) neonates being classified as SGA. Compared with non-SGA neonates, this newly identified group had an increased risk of perinatal mortality (OR 3.2; 95% CI 1.6 to 6.2), neurological morbidity (OR 3.2; 95% CI 1.7 to 6.1) and non-neurological morbidity (OR 8; 95% CI 4.8 to 13.6).
CONCLUSION: Customised standards improve the prediction of adverse neonatal outcome. The association between SGA and adverse outcome is independent of the gestational age at delivery.
Francesc Figueras; Josep Figueras; Eva Meler; Elisenda Eixarch; Oriol Coll; Eduard Gratacos; Jason Gardosi; Xavier Carbonell
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Publication Detail:
Type:  Journal Article     Date:  2007-01-24
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  92     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-22     Completed Date:  2007-07-12     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F277-80     Citation Subset:  AIM; IM    
Perinatal Institute, Crystal Court, Aston Cross, Birmingham, UK.
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MeSH Terms
Birth Weight*
Fetal Growth Retardation / epidemiology
Gestational Age
Infant, Newborn
Infant, Newborn, Diseases / embryology*,  epidemiology
Infant, Small for Gestational Age*
Pregnancy Outcome
Reference Values
Retrospective Studies
Spain / epidemiology

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