Document Detail


Customised birthweight centiles are useful for identifying small-for-gestational-age babies in women with type 2 diabetes.
MedLine Citation:
PMID:  19432607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Customised birthweight centiles identify small-for-gestational-age (SGA) babies at increased risk of morbidity more accurately than population centiles, but they have not been validated in obese populations. AIMS: To compare the rates of SGA by population and customised birthweight centiles in babies of women with type 2 diabetes and examine perinatal outcomes in customised SGA infants. METHODS: Data were from a previous retrospective cohort study detailing pregnancy outcomes in 212 women with type 2 diabetes. Customised and population birthweight centiles were calculated; pregnancy details and neonatal outcomes were compared between groups that delivered infants who were SGA (birthweight < 10th customised centile) and appropriate weight for gestational age (AGA) (birthweight 10-90th customised centile). RESULTS: Fifteen (7%) babies were SGA by population centiles and 32 (15%) by customised centiles. Two babies of Indian women were reclassified from SGA to AGA by customised centiles. Nineteen babies were reclassified from AGA to SGA by customised centiles; of these, 15 (79%) were born to Polynesian women, five (26%) were born less than 32 weeks and two (11%) were stillborn. Customised SGA infants, compared with AGA infants, were more likely to be born preterm (19 (59%) vs 20 (16%), P < 0.001) and more likely to be stillborn (4 (13%) vs 0 P = 0.001). After excluding still births, admission to the neonatal unit was also more common (19 of 28 (68%) vs 43 of 127 (34%), P < 0.001). CONCLUSIONS: In our population more babies were classified as SGA by customised compared with population centiles. These customised SGA babies have high rates of morbidity.
Authors:
Janet A Rowan; Steven Luen; Ruth C Hughes; Lynn C Sadler; Lesley M E McCowan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  49     ISSN:  1479-828X     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-12     Completed Date:  2009-08-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, National Women's Hospital, Auckland, New Zealand. jrowan@internet.co.nz
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight*
Body Mass Index
Cohort Studies
Diabetes Mellitus, Type 2 / complications*,  drug therapy
Female
Humans
Hypoglycemic Agents / therapeutic use
Infant, Newborn
Infant, Premature
Infant, Small for Gestational Age*
Metformin / therapeutic use
Pregnancy
Pregnancy in Diabetics*
Reference Values
Retrospective Studies
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 657-24-9/Metformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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