| Cushing's syndrome in pregnancy. | |
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MedLine Citation:
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PMID: 22696666 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 22-year-old G(1)P(0) was admitted at 26 weeks gestation for preeclampsia, hyperglycaemia and cushingoid features. Elevated 24-h urine free cortisol (UFC) and suppressed plasma adrenocorticotrophic hormone (ACTH) suggested ACTH-independent Cushing's syndrome. Ultrasound showed left adrenal mass. She delivered preterm at 28 weeks due to severe preeclampsia and fetal distress. The infant expired after 4 days. Blood pressure was controlled after delivery and the patient was discharged on ketoconazole. Adrenalectomy was planned postpartum; however, she withdrew consent and was lost to follow-up. A 33-year-old G(1)P(1) presented with gestational diabetes. Pregnancy was complicated by premature delivery at 31 weeks for fetal distress. The baby improved and survived. Three months postpartum, she was evaluated for osteoporosis after sustaining a fracture from a fall. Cushingoid facies, elevated 24-h UFC, suppressed ACTH and a right adrenal mass on MRI confirmed an ACTH-independent Cushing's syndrome. She underwent adrenalectomy and improved. |
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Authors:
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Margarita Victoria B Holgado-Galicia; Jose Donato Magno; Czarlota Acelajado-Valdenor; Iris Thiele Isip-Tan; Mary Anne Lim-Abrahan |
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Publication Detail:
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Type: Journal Article Date: 2011-04-26 |
Journal Detail:
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Title: BMJ case reports Volume: 2011 ISSN: 1757-790X ISO Abbreviation: BMJ Case Rep Publication Date: 2011 |
Date Detail:
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Created Date: 2012-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101526291 Medline TA: BMJ Case Rep Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: IM |
Affiliation:
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Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of the Philippines Manila, Philippine General Hospital, Manila, Philippines. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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