Document Detail


Cushing's syndrome in pregnancy: report of a case and review of the literature.
MedLine Citation:
PMID:  17724009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cushing's syndrome (CS) during pregnancy is a rare nosology with only a few cases reported in the literature. Misdiagnosis is common, as the syndrome may be easily confused with preeclampsia or gestational diabetes. CS during pregnancy is usually associated with severe maternal and fetal complications. A high degree of clinical awareness is therefore required to avoid miscarriage or premature delivery. We report an 18-year old female referred to our institution with amenorrhea and truncal obesity. Physical examination revealed cushingoid characteristics, including mild hypertension (130/100 mmHg). She was also found to be 8 weeks pregnant. A provisional diagnosis of CS was made based on plasma cortisol and adrenocorticotropin hormone (ACTH) measurements but the patient did not receive any relevant therapy. She eventually gave birth to a healthy full-term infant via vaginal delivery. A right adrenal adenoma was diagnosed post-labor and was subsequently treated with surgical resection. The patient's condition remained stable and 19 months after the adrenalectomy she gave birth to a second healthy full-term infant. Hydrocortisone (30 mg/day) was administered throughout the second gestation. Six months post-labor the treatment was discontinued after a normal hypothalamic-pituitary-adrenal (HPA) axis was ascertained.
Authors:
Marina Kita; Maria Sakalidou; Athanasios Saratzis; Sarris Ioannis; Avraam Avramidis
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  6     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2007-08-28     Completed Date:  2007-11-05     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  242-6     Citation Subset:  IM    
Affiliation:
Department of Endocrinology, Hippocration General Hospital, Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Cushing Syndrome / diagnosis*,  radiography
Female
Hormones / blood
Humans
Pregnancy
Pregnancy Complications / diagnosis*,  radiography
Pregnancy Outcome
Chemical
Reg. No./Substance:
0/Hormones

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