Document Detail


Cushing's syndrome due to a non-adrenal ectopic adrenocorticotropin-secreting Ewing's sarcoma in a child.
MedLine Citation:
PMID:  19554811     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ectopic ACTH syndrome (EAS) is extremely rare in the pediatric age group. Sarcomatous tumors causing EAS are even rarer. We report a 9 year-old girl presenting with Cushing's syndrome caused by ectopic ACTH production by a Ewing's sarcoma. This case illustrates that rapid appearance of Cushingoid symptoms, absence of growth retardation and the presence of hypokalemia are suggestive clues for ectopic ACTH production as the source of Cushing's syndrome.
Authors:
Tulay Guran; Serap Turan; Behzat Ozkan; Su Gulsun Berrak; Cengiz Canpolat; Tolga Dagli; Funda Sirin Eren; Abdullah Bereket
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  22     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Affiliation:
Pediatric Endocrinology and Diabetes, Marmara University, Istanbul, Turkey. tulayguran@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
ACTH Syndrome, Ectopic / complications*
Adrenocorticotropic Hormone / secretion*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child
Cushing Syndrome / drug therapy,  etiology*
Cyclophosphamide / therapeutic use
Doxorubicin / therapeutic use
Female
Humans
Retroperitoneal Neoplasms / complications,  drug therapy
Sarcoma, Ewing's / complications*,  drug therapy
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
0/CAV protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 57-22-7/Vincristine; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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