| Cushing's syndrome caused by topical steroid therapy for psoriasis. | |
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MedLine Citation:
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PMID: 12164372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 72-year-old woman developed manifestations of Cushing's syndrome after long-term topical steroid therapy for psoriasis. Shortly after tapering the dose of topical steroids she developed signs of adrenal insufficiency (provoked by a urinary tract infection) requiring intravenous administration of a stress dose of hydrocortisone. There have only been a few reports of systemic side effects of topically applied corticosteroids in adults. Considering their serious consequences physicians should be alert to signs of Cushing's syndrome in patients on long-term topical steroid therapy. Furthermore, clobetasol propionate ointment doses exceeding 50 g a week should not be prescribed and use of occlusive dressings should be avoided. |
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Authors:
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E M Abma; R Blanken; L J M De Heide |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 60 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-08-07 Completed Date: 2002-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 148-50 Citation Subset: IM |
Affiliation:
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Medical Centre Leeuwarden, Department of Internal Medicine, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adrenal Insufficiency / chemically induced Aged Anti-Inflammatory Agents / adverse effects* Clobetasol / adverse effects*, analogs & derivatives* Cushing Syndrome / chemically induced* Female Glucocorticoids Humans Psoriasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Glucocorticoids; 25122-41-2/Clobetasol |
| Comments/Corrections | |
Comment In:
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Neth J Med. 2002 Apr;60(3):130-2
[PMID:
12164369
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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