Document Detail


Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms.
MedLine Citation:
PMID:  20739379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Several studies have reported an association between idiopathic intracranial hypertension (IIH) and deficits of the hypothalamic-pituitary-adrenal (HPA) axis.
CASE ILLUSTRATION: A 33-yr-old woman with Cushing's disease underwent successful surgical resection of a pituitary adenoma and developed IIH 11 months later after inadvertent withdrawal of oral glucocorticoids.
METHODS: A review of the literature was conducted to identify previous studies pertaining to IIH in association with neuroendocrine disease, focusing on reports related to HPA axis dysfunction.
RESULTS: A number of patients developing IIH due to a relative deficiency in glucocorticoids, after surgical or medical management for Cushing's disease, withdrawal from glucocorticoid replacement, or as an initial presentation of Addison's disease, have been reported. Hypotheses regarding the underlying pathophysiology of IIH in this context and, in particular, the role of cortisol and its relationship to other neuroendocrine and inflammatory mediators that may regulate the homeostasis of cerebrospinal fluid production and absorption are reviewed.
CONCLUSION: In a subset of patients, dysfunction of the HPA axis appears to play a role in the development of IIH. Hormonal control of cerebrospinal fluid production and absorption may be regulated by inflammatory mediators and the enzyme 11ß-hydroxysteroid dehydrogenase type 1. Further study of neuroendocrine markers in the serum and cerebrospinal fluid may be an avenue for further research in IIH.
Authors:
Gabriel Zada; Amir Tirosh; Ursula B Kaiser; Edward R Laws; Whitney W Woodmansee
Related Documents :
15070029 - Industrial solvents and kidney disease.
10356409 - Two recent cases of tertiary syphilis.
20420699 - Primary nasopharyngeal hodgkin's disease: case report and literature review.
3911729 - Creutzfeldt-jakob disease. an autopsy case of the panencephalopathic type and a review ...
11446679 - The spectrum of cftr-related disease.
20972189 - Pos02 moyamoya disease: a uk single centre experience.
7593799 - Superficial papillary adenomatosis of the nipple: a case report and review of the liter...
21185719 - Herbal therapy use by cancer patients: a literature review on case reports.
12827059 - Insect wing conjunctival granuloma.
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-08-25
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-10     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4850-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. gzada@usc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoma / complications*,  surgery
Adult
Female
Glucocorticoids / adverse effects*
Humans
Pituitary ACTH Hypersecretion / complications*,  surgery
Pituitary Neoplasms / complications*,  surgery
Pseudotumor Cerebri / chemically induced,  complications*
Substance Withdrawal Syndrome*
Chemical
Reg. No./Substance:
0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorp...
Next Document:  Familial longevity is associated with decreased thyroid function.