| Cushing syndrome and adrenal carcinoma: a clinical case. | |
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MedLine Citation:
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PMID: 19537129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 21-year-old girl arrived at our hospital with a short history of hirsutism, facial pletora, amenorrhea, progressive weight gain and hypertension. The clinically suspected Cushing syndrome was then confirmed through chemical pathology. In fact, the results from hemato-chemical exams were: 45.5 Ig/dl cortisol, a DHEA sulphate >8000 ng/ml, 7.2 pg/ml ACTH, 17OH-Progesterone 10.66 ng/ml, Delta-4 Androstenedione 5.2 ng/ml, UFC (Urine Free Cortisol) >1000 mg/24h, FSH 0.8 mUI/ml, LH < 0.1 mUI/ml, Prolactin 13, 17, estradiol 96 pg/ml, and a bonded hypokalaemia, K+ 2,4 mEq/L. The echogram of the complete abdomen reveals, near the superior pole of the left kidney, the presence of a solid mass, not independent from the pole itself about 9.5 centimetres long, diagnosis confirmed to the TC abdomen and pelvis too, with or without mdc. This removed mass resulted, from the histological exam, in an adrenal carcinoma with a general and trabecular structure. Primal adrenal tumours are responsible for about 10% of Cushing syndrome cases. They present an annual incidence of 0.5 - 2.0 cases per million of inhabitants. The prognosis of adrenal ca remains low, with 5 year survival rate for 38% of diagnosed patients. |
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Authors:
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Giancarlo Candela; Sergio Varriale; Fiorenza Manetta; Lorenzo Di Libero; Marco Giordano; Luigi Santini |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annali italiani di chirurgia Volume: 80 ISSN: 0003-469X ISO Abbreviation: Ann Ital Chir Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-06-19 Completed Date: 2009-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372343 Medline TA: Ann Ital Chir Country: Italy |
Other Details:
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Languages: eng Pagination: 75-81 Citation Subset: IM |
Affiliation:
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VII Division of General Surgery, Seconda Università degli Studi di Napoli S.U.N, Napoli, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Neoplasms
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chemistry,
complications,
diagnosis*,
pathology,
surgery Adrenocortical Carcinoma / chemistry, complications, diagnosis*, pathology, surgery Adrenocorticotropic Hormone / blood Adult Amenorrhea / etiology Androstenedione / blood Cushing Syndrome / diagnosis*, etiology, metabolism, surgery Dehydroepiandrosterone / blood Estradiol / blood Female Follicle Stimulating Hormone / blood Hirsutism / etiology Humans Hydrocortisone / blood, urine Hypertension / etiology Potassium / blood Progesterone / blood Prognosis Prolactin / blood Treatment Outcome Tumor Markers, Biological / blood*, urine Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone; 57-83-0/Progesterone; 63-05-8/Androstenedione; 7440-09-7/Potassium; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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