Document Detail


Curve-shift analysis of self-stimulation in food-restricted rats: relationship between daily meal, plasma corticosterone and reward sensitization.
MedLine Citation:
PMID:  8556330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic food restriction lowers the threshold for lateral hypothalamic electrical self-stimulation (LHSS). This effect has previously been interpreted to reflect a sensitization of reward. In the present study a curve-shift method was used to explicitly differentiate effects of food restriction on brain stimulation rewarding efficacy and performance. Food restriction consistently shifted rate-frequency curves to the left, lowering the M-50 and Theta-0 parameters of rewarding efficacy. Asymptotic rates of reinforcement and slopes of rate-frequency functions were unaffected, confirming that food restriction does not facilitate LHSS by enhancing performance. In this and previous studies, LHSS in food-restricted rats was measured in the period immediately preceding the daily meal when hunger (i.e., period since last meal) and plasma corticosterone are at peak levels. In the light of evidence that corticosterone may regulate sensitivity of the mesolimbic dopamine pathway and account for the sensitizing effect of stress on psychomotor effects of opiates and stimulants, LHSS and corticosterone were measured in the immediate pre-and post-meal periods. While all food-restricted rats displayed elevated corticosterone levels in the pre-meal period and generally displayed a decline to control levels in the post-meal period, the sensitization of reward was not reversed in the post-meal period. These results indicate that chronic food restriction produces a sensitization of reward that does not depend upon the acute state of hunger that precedes the daily meal and does not vary with dynamic changes in plasma corticosterone level.
Authors:
G C Abrahamsen; Y Berman; K D Carr
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  695     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-02-27     Completed Date:  1996-02-27     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  186-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology
Corticosterone / blood*
Eating / physiology*
Electric Stimulation
Electrodes, Implanted
Hypothalamic Area, Lateral / anatomy & histology,  physiology
Male
Rats
Rats, Sprague-Dawley
Reward*
Self Stimulation / physiology*
Grant Support
ID/Acronym/Agency:
DA-03956/DA/NIDA NIH HHS; T32 DA-07254/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
W980KJ009P/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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