Document Detail

Curtailed respiration by repeated vs. isolated hypoxia in maturing piglets is unrelated to NTS ME or SP levels.
MedLine Citation:
PMID:  9262448     Owner:  NLM     Status:  MEDLINE    
In early development, respiratory disorders can produce recurring hypoxic episodes during sleep. To examine possible effects of daily repeated vs. isolated hypoxic hypoxia, cardiorespiratory functions and central, respiratory-related neuromodulator levels in 21- to 32-day-old, chronically instrumented, unsedated piglets were compared between a fifth sequential daily hypoxia and an isolated hypoxia (10% O2-90% N2 for 30 min). Diaphragmatic electromyographic activity, heart rate and arterial pressure, and pH and gas tensions were measured. In vivo microdialysis, via chronically implanted guides, served to sample interstitial substance P (SP) and methionine-enkephalin (ME) at the level of the respiratory-related nucleus tractus solitarii (NTS). Compared with an isolated hypoxia, repeated hypoxia resulted in 1) lower respiratory frequency (f), ventilation equivalent, and arterial pH, higher arterial PO2 during hypoxia, and lower f in recovery from hypoxia; and 2) increased SP concentrations but no change in ME concentrations. We conclude that, in these maturing swine, repeated vs. isolated hypoxic exposure curtails respiratory responses to hypoxia by a mechanism(s) unrelated to SP or ME levels at the NTS.
K A Waters; A Laferrière; J Paquette; C Goodyer; I R Moss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  83     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-15     Completed Date:  1997-09-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  522-9     Citation Subset:  IM    
Department of Pediatrics, McGill University, and The Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3.
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MeSH Terms
Aging / physiology*
Animals, Newborn / growth & development,  physiology*
Anoxia / metabolism,  physiopathology*
Enkephalin, Methionine / metabolism*
Solitary Nucleus / metabolism*
Substance P / metabolism*
Swine, Miniature
Grant Support
Reg. No./Substance:
33507-63-0/Substance P; 58569-55-4/Enkephalin, Methionine

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